6-Chloro-7-hydroxy-4-methylcoumarin

Cat. No.: HY-128416 Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

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6-Chloro-7-hydroxy-4-methylcoumarin (compound 3) an intermediate of pharmaceutical synthesis.

For research use only. We do not sell to patients.

6-Chloro-7-hydroxy-4-methylcoumarin Chemical Structure

CAS No. : 19492-02-5

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

6-Chloro-7-hydroxy-4-methylcoumarin (compound 3) an intermediate of pharmaceutical synthesis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
U-937	CC₅₀	734.3 μM Compound: 9	Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay	[PMID: 22925447]
U-937	IC₅₀	771.3 μM Compound: 9	Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting	[PMID: 22925447]

Molecular Weight

210.61

Formula

C₁₀H₇ClO₃

CAS No.

19492-02-5

Appearance

Solid

Color

Off-white to gray

SMILES

O=C1C=C(C)C2=CC(Cl)=C(O)C=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (237.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7481 mL	23.7406 mL	47.4811 mL
5 mM	0.9496 mL	4.7481 mL	9.4962 mL
10 mM	0.4748 mL	2.3741 mL	4.7481 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (249 KB) HNMR (242 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Hong Dai, et al. Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids. Eur J Med Chem. 2019 Mar 15;166:470-479. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7481 mL	23.7406 mL	47.4811 mL	118.7028 mL
	5 mM	0.9496 mL	4.7481 mL	9.4962 mL	23.7406 mL
	10 mM	0.4748 mL	2.3741 mL	4.7481 mL	11.8703 mL
	15 mM	0.3165 mL	1.5827 mL	3.1654 mL	7.9135 mL
	20 mM	0.2374 mL	1.1870 mL	2.3741 mL	5.9351 mL
	25 mM	0.1899 mL	0.9496 mL	1.8992 mL	4.7481 mL
	30 mM	0.1583 mL	0.7914 mL	1.5827 mL	3.9568 mL
	40 mM	0.1187 mL	0.5935 mL	1.1870 mL	2.9676 mL
	50 mM	0.0950 mL	0.4748 mL	0.9496 mL	2.3741 mL
	60 mM	0.0791 mL	0.3957 mL	0.7914 mL	1.9784 mL
	80 mM	0.0594 mL	0.2968 mL	0.5935 mL	1.4838 mL
	100 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1870 mL