6-Dehydronandrolone acetate

Name: 6-Dehydronandrolone acetate
Brand: MedChemExpress
SKU: HY-79315
Rating: 4.5 (1 reviews)

Cat. No.: HY-79315 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

6-Dehydronandrolone acetate is a starting material for synthesis of Fulvestrant. Fulvestrant is an estrogen receptor antagonist that can be used for the research of breast cancer.

For research use only. We do not sell to patients.

6-Dehydronandrolone acetate Chemical Structure

CAS No. : 2590-41-2

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Proteins:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

6-Dehydronandrolone acetate is a starting material for synthesis of Fulvestrant. Fulvestrant is an estrogen receptor antagonist that can be used for the research of breast cancer^[1].

In Vitro

Fulvestrant can be synthesized in four steps (35% overall yield) from 6-Dehydronandrolone acetate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

314.42

Formula

C₂₀H₂₆O₃

CAS No.

2590-41-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1CC[C@@]2([H])C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4OC(C)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (636.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1805 mL	15.9023 mL	31.8046 mL
5 mM	0.6361 mL	3.1805 mL	6.3609 mL
10 mM	0.3180 mL	1.5902 mL	3.1805 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (248 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Caprioglio D, et, al. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation. Chem Commun (Camb). 2015 Oct 14;51(80):14866-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1805 mL	15.9023 mL	31.8046 mL	79.5115 mL
	5 mM	0.6361 mL	3.1805 mL	6.3609 mL	15.9023 mL
	10 mM	0.3180 mL	1.5902 mL	3.1805 mL	7.9511 mL
	15 mM	0.2120 mL	1.0602 mL	2.1203 mL	5.3008 mL
	20 mM	0.1590 mL	0.7951 mL	1.5902 mL	3.9756 mL
	25 mM	0.1272 mL	0.6361 mL	1.2722 mL	3.1805 mL
	30 mM	0.1060 mL	0.5301 mL	1.0602 mL	2.6504 mL
	40 mM	0.0795 mL	0.3976 mL	0.7951 mL	1.9878 mL
	50 mM	0.0636 mL	0.3180 mL	0.6361 mL	1.5902 mL
	60 mM	0.0530 mL	0.2650 mL	0.5301 mL	1.3252 mL
	80 mM	0.0398 mL	0.1988 mL	0.3976 mL	0.9939 mL
	100 mM	0.0318 mL	0.1590 mL	0.3180 mL	0.7951 mL