2. Academic Validation
  3. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

  • Chem Commun (Camb). 2015 Oct 14;51(80):14866-8. doi: 10.1039/c5cc05805h.
Diego Caprioglio 1,  Stephen P Fletcher
Affiliations

Affiliation

  • 1 Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield road, OX1 3TA, UK. stephen.fletcher@chem.ox.ac.uk.
PMID: 26300021 DOI: 10.1039/c5cc05805h
Abstract

Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

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