2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 6-Hydroxy-DOPA

6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer.

For research use only. We do not sell to patients.

6-Hydroxy-DOPA Chemical Structure

6-Hydroxy-DOPA Chemical Structure

CAS No. : 21373-30-8

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5 mg USD 130 In-stock
10 mg USD 208 In-stock
25 mg USD 416 In-stock
50 mg USD 665 In-stock
100 mg USD 998 In-stock
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Based on 1 publication(s) in Google Scholar

6-Hydroxy-DOPA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer[1].

IC50 & Target

RAD52[1]
In Vitro

6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Hydroxy-DOPA Related Antibodies
Molecular Weight

213.19

Formula

C9H11NO5
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

OC(C(N)CC1=C(C=C(O)C(O)=C1)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (234.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6907 mL 23.4533 mL 46.9065 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6907 mL 23.4533 mL 46.9065 mL 117.2663 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL 23.4533 mL
10 mM 0.4691 mL 2.3453 mL 4.6907 mL 11.7266 mL
15 mM 0.3127 mL 1.5636 mL 3.1271 mL 7.8178 mL
20 mM 0.2345 mL 1.1727 mL 2.3453 mL 5.8633 mL
25 mM 0.1876 mL 0.9381 mL 1.8763 mL 4.6907 mL
30 mM 0.1564 mL 0.7818 mL 1.5636 mL 3.9089 mL
40 mM 0.1173 mL 0.5863 mL 1.1727 mL 2.9317 mL
50 mM 0.0938 mL 0.4691 mL 0.9381 mL 2.3453 mL
60 mM 0.0782 mL 0.3909 mL 0.7818 mL 1.9544 mL
80 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
100 mM 0.0469 mL 0.2345 mL 0.4691 mL 1.1727 mL
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6-Hydroxy-DOPA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Hydroxy-DOPA21373-30-8DNA/RNA SynthesisselectiveeffectiveallostericssDNAcancerU20SHCC1937Inhibitorinhibitorinhibit

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