6-O-Methyl-guanine

Cat. No.: HY-W013591 Purity: 98.92%: FAQs
Data Sheet SDS COA Handling Instructions

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6-O-Methyl-guanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

6-O-Methyl-guanine Chemical Structure

CAS No. : 20535-83-5

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5 g	USD 25	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 6-O-Methyl-guanine:

6-O-Methyl-guanine-d₃ Get quote
6-O-Methyl-guanine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

6-O-Methyl-guanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-HSB-2	CC₅₀	> 20 μM Compound: AMP	Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
HFF	IC₅₀	> 300 μM Compound: AMP	Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 300 μM Compound: AMP	Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	CC₅₀	171 μM Compound: AMP	Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining	[PMID: 22607883]
HFF	IC₅₀	2.8 μM Compound: AMP	Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay	[PMID: 22607883]
HFF	IC₅₀	7.4 μM Compound: AMP	Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining	[PMID: 22607883]
MOLT-3	CC₅₀	> 20 μM Compound: AMP	Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
MOLT-3	IC₅₀	> 20 μM Compound: AMP	Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay	[PMID: 22607883]

Molecular Weight

165.15

Formula

C₆H₇N₅O

CAS No.

20535-83-5

Appearance

Solid

SMILES

NC1=NC(OC)=C2N=CNC2=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (121.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0551 mL	30.2755 mL	60.5510 mL
5 mM	1.2110 mL	6.0551 mL	12.1102 mL
10 mM	0.6055 mL	3.0276 mL	6.0551 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (251 KB) HNMR (119 KB) RP-HPLC (100 KB)

Handling Instructions (2659 KB)

References

[1]. Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.0551 mL	30.2755 mL	60.5510 mL	151.3775 mL
	5 mM	1.2110 mL	6.0551 mL	12.1102 mL	30.2755 mL
	10 mM	0.6055 mL	3.0276 mL	6.0551 mL	15.1378 mL
	15 mM	0.4037 mL	2.0184 mL	4.0367 mL	10.0918 mL
	20 mM	0.3028 mL	1.5138 mL	3.0276 mL	7.5689 mL
	25 mM	0.2422 mL	1.2110 mL	2.4220 mL	6.0551 mL
	30 mM	0.2018 mL	1.0092 mL	2.0184 mL	5.0459 mL
	40 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7844 mL
	50 mM	0.1211 mL	0.6055 mL	1.2110 mL	3.0276 mL
	60 mM	0.1009 mL	0.5046 mL	1.0092 mL	2.5230 mL
	80 mM	0.0757 mL	0.3784 mL	0.7569 mL	1.8922 mL
	100 mM	0.0606 mL	0.3028 mL	0.6055 mL	1.5138 mL