2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Drug Metabolite Opioid Receptor
  4. 6β-Naltrexol

6β-Naltrexol  (Synonyms: 6β-Hydroxynaltrexone)

Cat. No.: HY-108229
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6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit.

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6β-Naltrexol Chemical Structure

6β-Naltrexol Chemical Structure

CAS No. : 49625-89-0

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Based on 1 publication(s) in Google Scholar

6β-Naltrexol Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
1.2 nM
Compound: 2
Inverse agonist activity at human recombinant mu opioid receptor expressed in CHO cells after 3 hrs by [35S]GTPgammaS binding assay
Inverse agonist activity at human recombinant mu opioid receptor expressed in CHO cells after 3 hrs by [35S]GTPgammaS binding assay
[PMID: 22771010]
Molecular Weight

343.42

Formula

C20H25NO4
CAS No.
SMILES

O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC6CC6)CC4)C=CC(O)=C5O[C@@]3([H])[C@H](O)CC1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6β-Naltrexol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6β-Naltrexol49625-89-06β-HydroxynaltrexoneDrug MetaboliteOpioid Receptorgastrointestinal transitwell-toleratednaltrexoneMorphineInhibitorinhibitorinhibit

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