7-Methoxytacrine (Synonyms: 7-MEOTA)

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7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC₅₀ value of 10 μM, and can be used for the research of Alzheimer's disease (AD).

For research use only. We do not sell to patients.

7-Methoxytacrine Chemical Structure

CAS No. : 5778-80-3

Size	Price	Stock	Quantity
1 mg	USD 350	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	USD 780	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	USD 1110	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC₅₀ value of 10 μM, and can be used for the research of Alzheimer's disease (AD)^[1].

IC₅₀ & Target

hAChE

10.5 μM (IC₅₀)

hBCHE

21 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	63 μM Compound: 7-MEOTA; 1	Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 30851693]
HepG2	IC₅₀	11.5 μM Compound: 2; 7-MEOTA	Hepatotoxicity in human HepG2 cells assessed as cell viability after 24 hrs by MTT assay Hepatotoxicity in human HepG2 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 26503905]
HepG2	IC₅₀	120 μM Compound: 7-MEOTA; 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 30851693]
HepG2	IC₅₀	44.37 μM Compound: 7-MEOTA	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 33984470]
HepG2	IC₅₀	44.37 μM Compound: 7-MEOTA	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29533874]

Molecular Weight

228.29

Formula

C₁₄H₁₆N₂O

CAS No.

5778-80-3

SMILES

NC1=C(CCCC2)C2=NC3=CC=C(OC)C=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Spilovska K, et al. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies. Molecules. 2013;18(2):2397-2418. Published 2013 Feb 20. [Content Brief]

7-Methoxytacrine Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Methoxytacrine5778-80-37-MEOTACholinesterase (ChE)Alzheimer’s disease (AD)Inhibitorinhibitorinhibit

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