8-iso Prostaglandin F2α-d₉

Cat. No.: HY-113209S1: FAQs
Data Sheet Handling Instructions

Molarity Calculator

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

For research use only. We do not sell to patients.

8-iso Prostaglandin F2α-d<sub>9</sub> Chemical Structure

8-iso Prostaglandin F2α-d₉ Chemical Structure

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of 8-iso Prostaglandin F2α-d₉:

8-Isoprostaglandin F2α Get quote
ent-8-Iso-15(S)-prostaglandin F2α Get quote
8-Iso-PGF2a-d₄ Get quote
8-Isoprostaglandin F2α-¹³C₅ Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.54

Formula

C₂₀H₂₅D₉O₅

Unlabeled CAS

27415-26-5

SMILES

O[C@@H]([C@@H]1C/C=C\CCCC(O)=O)C[C@@H]([C@H]1/C=C/[C@H](CC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (275.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7507 mL	13.7536 mL	27.5073 mL
5 mM	0.5501 mL	2.7507 mL	5.5015 mL
10 mM	0.2751 mL	1.3754 mL	2.7507 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7507 mL	13.7536 mL	27.5073 mL	68.7682 mL
	5 mM	0.5501 mL	2.7507 mL	5.5015 mL	13.7536 mL
	10 mM	0.2751 mL	1.3754 mL	2.7507 mL	6.8768 mL
	15 mM	0.1834 mL	0.9169 mL	1.8338 mL	4.5845 mL
	20 mM	0.1375 mL	0.6877 mL	1.3754 mL	3.4384 mL
	25 mM	0.1100 mL	0.5501 mL	1.1003 mL	2.7507 mL
	30 mM	0.0917 mL	0.4585 mL	0.9169 mL	2.2923 mL
	40 mM	0.0688 mL	0.3438 mL	0.6877 mL	1.7192 mL
	50 mM	0.0550 mL	0.2751 mL	0.5501 mL	1.3754 mL
	60 mM	0.0458 mL	0.2292 mL	0.4585 mL	1.1461 mL
	80 mM	0.0344 mL	0.1719 mL	0.3438 mL	0.8596 mL
	100 mM	0.0275 mL	0.1375 mL	0.2751 mL	0.6877 mL