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  4. (9R,12aR)-AZD4747

(9R,12aR)-AZD4747 is a diastereomer of AZD4747 (HY-154959). AZD4747 is a selective mutant GTPase KRASG12C inhibitor with blood-brain barrier permeability. AZD4747 has the potential to study cancer.

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(9R,12aR)-AZD4747 Chemical Structure

(9R,12aR)-AZD4747 Chemical Structure

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 650 In-stock
10 mg USD 1040 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of (9R,12aR)-AZD4747:

(9R,12aR)-AZD4747 Related Antibodies

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Description

(9R,12aR)-AZD4747 is a diastereomer of AZD4747 (HY-154959). AZD4747 is a selective mutant GTPase KRASG12C inhibitor with blood-brain barrier permeability. AZD4747 has the potential to study cancer[1].

Molecular Weight

440.89

Formula

C24H22ClFN2O3
Appearance

Solid

Color

White to off-white

SMILES

C=CC(N(C[C@@H]1COC2=C3F)CCN1CC2=CC(C#CC)=[C@@]3[C@]4=C(C=CC=C4O)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (283.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2681 mL 11.3407 mL 22.6814 mL
5 mM 0.4536 mL 2.2681 mL 4.5363 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2681 mL 11.3407 mL 22.6814 mL 56.7035 mL
5 mM 0.4536 mL 2.2681 mL 4.5363 mL 11.3407 mL
10 mM 0.2268 mL 1.1341 mL 2.2681 mL 5.6703 mL
15 mM 0.1512 mL 0.7560 mL 1.5121 mL 3.7802 mL
20 mM 0.1134 mL 0.5670 mL 1.1341 mL 2.8352 mL
25 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2681 mL
30 mM 0.0756 mL 0.3780 mL 0.7560 mL 1.8901 mL
40 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4176 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9451 mL
80 mM 0.0284 mL 0.1418 mL 0.2835 mL 0.7088 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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(9R,12aR)-AZD4747 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(9R,12aR)-AZD4747OthersdiastereoisomerInhibitorinhibitorinhibit

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