2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. AZD4747

AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.

For research use only. We do not sell to patients.

AZD4747 Chemical Structure

AZD4747 Chemical Structure

CAS No. : 2489226-14-2

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1 mg USD 314 In-stock
5 mg USD 786 In-stock
10 mg USD 1250 In-stock
25 mg USD 2626 In-stock
50 mg USD 4226 In-stock
100 mg USD 6750 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer[1].

IC50 & Target

KRASG12C[1].
In Vivo

AZD4747 (1.1-2.3 μM/kg (i.v.); 2.3-6.8 μM/kg (p.o.); single) shows clearances of moderate to high, with 52 and 75% of hepatic blood flow for the mouse and rat, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD1 mice, male Wistar Han rats[1].
Dosage: Mouse: 2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.);
Rat: 1.1-2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.).
Administration: i.v. and p.o.
Result: 1.19 Pharmacokinetic Parameters of AZD4747 in Cross Species[1].
Mouse Rat
IVa POa IVa POa
Eh (%) 52 75
Vss (L/kg) 2.9 1.7
T1/2 (h) 0.63 0.56
F% 58 18
Note:
a: 5% DMSO, 95% SBE-B-CD (30% w/v) in water.
Molecular Weight

440.89

Formula

C24H22ClFN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CC(N(C[C@@H]1COC2=C3F)CCN1CC2=CC(C#CC)=[C@]3[C@@]4=C(C=CC=C4O)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (567.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2681 mL 11.3407 mL 22.6814 mL
5 mM 0.4536 mL 2.2681 mL 4.5363 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2681 mL 11.3407 mL 22.6814 mL 56.7035 mL
5 mM 0.4536 mL 2.2681 mL 4.5363 mL 11.3407 mL
10 mM 0.2268 mL 1.1341 mL 2.2681 mL 5.6703 mL
15 mM 0.1512 mL 0.7560 mL 1.5121 mL 3.7802 mL
20 mM 0.1134 mL 0.5670 mL 1.1341 mL 2.8352 mL
25 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2681 mL
30 mM 0.0756 mL 0.3780 mL 0.7560 mL 1.8901 mL
40 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4176 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9451 mL
80 mM 0.0284 mL 0.1418 mL 0.2835 mL 0.7088 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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AZD4747 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD47472489226-14-2AZD 4747AZD-4747RascancerInhibitorinhibitorinhibit

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