Afloqualone (Synonyms: HQ-495)

Cat. No.: HY-B1833 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the GABAα receptor. Afloqualone has antivertiginous effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.

For research use only. We do not sell to patients.

Afloqualone Chemical Structure

CAS No. : 56287-74-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 79	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 79	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 52	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Afloqualone:

Afloqualone (Standard) Get quote

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Purity & Documentation
References
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Description

Molecular Weight

283.30

Formula

C₁₆H₁₄FN₃O

CAS No.

56287-74-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 33 mg/mL (116.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5298 mL	17.6491 mL	35.2983 mL
5 mM	0.7060 mL	3.5298 mL	7.0597 mL
10 mM	0.3530 mL	1.7649 mL	3.5298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)

References

[1]. T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. [Content Brief]

[2]. Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50(4):515-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5298 mL	17.6491 mL	35.2983 mL	88.2457 mL
	5 mM	0.7060 mL	3.5298 mL	7.0597 mL	17.6491 mL
	10 mM	0.3530 mL	1.7649 mL	3.5298 mL	8.8246 mL
	15 mM	0.2353 mL	1.1766 mL	2.3532 mL	5.8830 mL
	20 mM	0.1765 mL	0.8825 mL	1.7649 mL	4.4123 mL
	25 mM	0.1412 mL	0.7060 mL	1.4119 mL	3.5298 mL
	30 mM	0.1177 mL	0.5883 mL	1.1766 mL	2.9415 mL
	40 mM	0.0882 mL	0.4412 mL	0.8825 mL	2.2061 mL
	50 mM	0.0706 mL	0.3530 mL	0.7060 mL	1.7649 mL
	60 mM	0.0588 mL	0.2942 mL	0.5883 mL	1.4708 mL
	80 mM	0.0441 mL	0.2206 mL	0.4412 mL	1.1031 mL
	100 mM	0.0353 mL	0.1765 mL	0.3530 mL	0.8825 mL

Afloqualone Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Afloqualone56287-74-2HQ-495HQ495HQ 495GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorLVN neuronmethaqualoneanaloguemuscle-relaxantβ subtypeagonistantivertiginousInhibitorinhibitorinhibit

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