2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Anserine

Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice.

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Anserine Chemical Structure

Anserine Chemical Structure

CAS No. : 584-85-0

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100 mg USD 30 In-stock
500 mg USD 50 In-stock
1 g USD 70 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Anserine:

Anserine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Anserine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Anserine (drinking water at a concentration of 2.0 g/L (equivalent to 10 mg/mouse); for 8 weeks) completely recoveres the memory deficits, improves pericyte coverage on endothelial cells in the brain, and diminishes chronic glial neuroinflammatory reactions in AβPPswe/PSEN1dE9 Alzheimer's disease (AD) model mice over 18-months old[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

240.26

Formula

C10H16N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CC1=CN=CN1C)NC(CCN)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (416.22 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1622 mL 20.8108 mL 41.6216 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (416.22 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.85%

COA (248 KB) HNMR (267 KB) LCMS (90 KB) OR (172 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.1622 mL 20.8108 mL 41.6216 mL 104.0539 mL
5 mM 0.8324 mL 4.1622 mL 8.3243 mL 20.8108 mL
10 mM 0.4162 mL 2.0811 mL 4.1622 mL 10.4054 mL
15 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9369 mL
20 mM 0.2081 mL 1.0405 mL 2.0811 mL 5.2027 mL
25 mM 0.1665 mL 0.8324 mL 1.6649 mL 4.1622 mL
30 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
40 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
50 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0811 mL
60 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
80 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
100 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Anserine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anserine584-85-0Endogenous MetaboliteInhibitorinhibitorinhibit

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