2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis SARS-CoV Filovirus
  4. Galidesivir

Galidesivir  (Synonyms: BCX4430; Immucillin-A)

Cat. No.: HY-18649A Purity: 99.13%
COA Handling Instructions

Molarity Calculator

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.

For research use only. We do not sell to patients.

Galidesivir Chemical Structure

Galidesivir Chemical Structure

CAS No. : 249503-25-1

Size Price Stock Quantity
1 mg USD 200 In-stock
5 mg USD 600 In-stock
10 mg USD 960 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Galidesivir:

Galidesivir Related Antibodies

Top Publications Citing Use of Products

View All Filovirus Isoform Specific Products:

View All Isoforms
EBOV MARV ZEBOV

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3].

IC50 & Target

RdRp
In Vitro

Cellular kinases phosphorylate Galidesivir (BCX4430) to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination[1].
Galidesivir effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Galidesivir Related Antibodies
In Vivo

Galidesivir (BCX4430) is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy[1].
Galidesivir (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Syrian golden hamsters (hamsters infected with YF virus)[4]
Dosage: 4 mg/kg of body weight
Administration: I.p.; twice daily for 7 days
Result: Significantly improved the survival of hamsters infected with YFV.
Clinical Trial
Molecular Weight

265.27

Formula

C11H15N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](C2=CNC3=C2N=CN=C3N)N[C@H](CO)[C@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (376.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7697 mL 18.8487 mL 37.6974 mL
5 mM 0.7539 mL 3.7697 mL 7.5395 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.29%

COA (253 KB) HNMR (185 KB) LCMS (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.7697 mL 18.8487 mL 37.6974 mL 94.2436 mL
5 mM 0.7539 mL 3.7697 mL 7.5395 mL 18.8487 mL
10 mM 0.3770 mL 1.8849 mL 3.7697 mL 9.4244 mL
15 mM 0.2513 mL 1.2566 mL 2.5132 mL 6.2829 mL
20 mM 0.1885 mL 0.9424 mL 1.8849 mL 4.7122 mL
25 mM 0.1508 mL 0.7539 mL 1.5079 mL 3.7697 mL
30 mM 0.1257 mL 0.6283 mL 1.2566 mL 3.1415 mL
40 mM 0.0942 mL 0.4712 mL 0.9424 mL 2.3561 mL
50 mM 0.0754 mL 0.3770 mL 0.7539 mL 1.8849 mL
60 mM 0.0628 mL 0.3141 mL 0.6283 mL 1.5707 mL
80 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1780 mL
100 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9424 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Galidesivir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Galidesivir249503-25-1BCX4430 Immucillin-ABCX 4430BCX-4430DNA/RNA SynthesisSARS-CoVFilovirusSARS coronavirusadenosinenucleosideanalogvirusinfectionpathogenicCOVID-19Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Galidesivir
Cat. No.:
HY-18649A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.