2. Anti-infection
  3. Parasite
  4. BPH-715

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells.

For research use only. We do not sell to patients.

BPH-715 Chemical Structure

BPH-715 Chemical Structure

CAS No. : 1059677-23-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 362 In-stock
10 mg USD 544 In-stock
25 mg USD 969 In-stock
50 mg USD 1454 In-stock
100 mg USD 2182 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BPH-715 Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
10 μM
Compound: BPH-715
Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
[PMID: 20457823]
Molecular Weight

423.38

Formula

C17H31NO7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCOC1=C[N+](CC(P(O)(O)=O)P(O)([O-])=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.5 M NaOH : 80 mg/mL (188.96 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 5 mg/mL (11.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3619 mL 11.8097 mL 23.6194 mL
5 mM 0.4724 mL 2.3619 mL 4.7239 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.62%

SDS (251 KB)

COA (243 KB) HNMR (495 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.5 M NaOH 1 mM 2.3619 mL 11.8097 mL 23.6194 mL 59.0486 mL
5 mM 0.4724 mL 2.3619 mL 4.7239 mL 11.8097 mL
10 mM 0.2362 mL 1.1810 mL 2.3619 mL 5.9049 mL
0.5 M NaOH 15 mM 0.1575 mL 0.7873 mL 1.5746 mL 3.9366 mL
20 mM 0.1181 mL 0.5905 mL 1.1810 mL 2.9524 mL
25 mM 0.0945 mL 0.4724 mL 0.9448 mL 2.3619 mL
30 mM 0.0787 mL 0.3937 mL 0.7873 mL 1.9683 mL
40 mM 0.0590 mL 0.2952 mL 0.5905 mL 1.4762 mL
50 mM 0.0472 mL 0.2362 mL 0.4724 mL 1.1810 mL
60 mM 0.0394 mL 0.1968 mL 0.3937 mL 0.9841 mL
80 mM 0.0295 mL 0.1476 mL 0.2952 mL 0.7381 mL
100 mM 0.0236 mL 0.1181 mL 0.2362 mL 0.5905 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BPH-715 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPH-7151059677-23-4BPH715BPH 715ParasiteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BPH-715
Cat. No.:
HY-118224
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.