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  3. Neprilysin
  4. Candoxatril

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

For research use only. We do not sell to patients.

Candoxatril Chemical Structure

Candoxatril Chemical Structure

CAS No. : 123122-55-4

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Based on 1 publication(s) in Google Scholar

Candoxatril Related Antibodies

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Description

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

IC50 & Target

NEP[1].
In Vivo

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

515.64

Formula

C29H41NO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(CCCC1)C[C@@H](COCCOC)C(OC2=CC=C(CCC3)C3=C2)=O)N[C@H]4CC[C@@H](C(O)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (96.97 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9393 mL 9.6967 mL 19.3934 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[2]

Mice[2]
Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9393 mL 9.6967 mL 19.3934 mL 48.4834 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL 9.6967 mL
10 mM 0.1939 mL 0.9697 mL 1.9393 mL 4.8483 mL
15 mM 0.1293 mL 0.6464 mL 1.2929 mL 3.2322 mL
20 mM 0.0970 mL 0.4848 mL 0.9697 mL 2.4242 mL
25 mM 0.0776 mL 0.3879 mL 0.7757 mL 1.9393 mL
30 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.6161 mL
40 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2121 mL
50 mM 0.0388 mL 0.1939 mL 0.3879 mL 0.9697 mL
60 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8081 mL
80 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL
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Candoxatril Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candoxatril123122-55-4UK 79300UK79300UK-79300NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10Inhibitorinhibitorinhibit

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