2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Crolibulin

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.

For research use only. We do not sell to patients.

Crolibulin Chemical Structure

Crolibulin Chemical Structure

CAS No. : 1000852-17-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 187 In-stock
Solution
10 mM * 1 mL in DMSO USD 187 In-stock
Solid
5 mg USD 170 In-stock
10 mg USD 280 In-stock
25 mg USD 490 In-stock
50 mg USD 730 In-stock
100 mg USD 980 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Crolibulin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Crolibulin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].

IC50 & Target

Tubulin polymerization[1]
In Vitro

Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC50 of 0.52 μM[2].
Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Crolibulin Related Antibodies
Clinical Trial
Molecular Weight

417.26

Formula

C18H17BrN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=C(N)OC2=C(N)C(N)=CC=C2[C@H]1C3=CC(OC)=C(OC)C(Br)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3966 mL 11.9829 mL 23.9659 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3966 mL 11.9829 mL 23.9659 mL 59.9147 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL 11.9829 mL
10 mM 0.2397 mL 1.1983 mL 2.3966 mL 5.9915 mL
15 mM 0.1598 mL 0.7989 mL 1.5977 mL 3.9943 mL
20 mM 0.1198 mL 0.5991 mL 1.1983 mL 2.9957 mL
25 mM 0.0959 mL 0.4793 mL 0.9586 mL 2.3966 mL
30 mM 0.0799 mL 0.3994 mL 0.7989 mL 1.9972 mL
40 mM 0.0599 mL 0.2996 mL 0.5991 mL 1.4979 mL
50 mM 0.0479 mL 0.2397 mL 0.4793 mL 1.1983 mL
60 mM 0.0399 mL 0.1997 mL 0.3994 mL 0.9986 mL
80 mM 0.0300 mL 0.1498 mL 0.2996 mL 0.7489 mL
100 mM 0.0240 mL 0.1198 mL 0.2397 mL 0.5991 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Crolibulin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crolibulin1000852-17-4EPC2407EPC 2407EPC-2407Microtubule/TubulinApoptosisantineoplasticanaplasticthyroidcancercolchicine-bindingsitecellcyclearrestapoptosisantiproliferativeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Crolibulin
Cat. No.:
HY-13603
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.