2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. DHBP dibromide

DHBP dibromide  (Synonyms: Diheptylviologen dibromide)

Cat. No.: HY-101237 Purity: 99.97%
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DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

For research use only. We do not sell to patients.

DHBP dibromide Chemical Structure

DHBP dibromide Chemical Structure

CAS No. : 6159-05-3

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Based on 1 publication(s) in Google Scholar

DHBP dibromide Related Antibodies

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View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

In Vitro

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHBP dibromide Related Antibodies
Molecular Weight

514.38

Formula

C24H38Br2N2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCCCCCC[N+]1=CC=C(C2=CC=[N+](CCCCCCC)C=C2)C=C1.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (194.41 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (58.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9441 mL 9.7204 mL 19.4409 mL
5 mM 0.3888 mL 1.9441 mL 3.8882 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (97.20 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9441 mL 9.7204 mL 19.4409 mL 48.6022 mL
5 mM 0.3888 mL 1.9441 mL 3.8882 mL 9.7204 mL
10 mM 0.1944 mL 0.9720 mL 1.9441 mL 4.8602 mL
15 mM 0.1296 mL 0.6480 mL 1.2961 mL 3.2401 mL
20 mM 0.0972 mL 0.4860 mL 0.9720 mL 2.4301 mL
25 mM 0.0778 mL 0.3888 mL 0.7776 mL 1.9441 mL
30 mM 0.0648 mL 0.3240 mL 0.6480 mL 1.6201 mL
40 mM 0.0486 mL 0.2430 mL 0.4860 mL 1.2151 mL
50 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9720 mL
H2O 60 mM 0.0324 mL 0.1620 mL 0.3240 mL 0.8100 mL
80 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6075 mL
100 mM 0.0194 mL 0.0972 mL 0.1944 mL 0.4860 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DHBP dibromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHBP dibromide6159-05-3Diheptylviologen dibromideCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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