11(Z),14(Z)-Eicosadienoic acid

Cat. No.: HY-149589 Purity: ≥98.0%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

11(Z),14(Z)-Eicosadienoic acid is a unsaturated fattly acid that inhibits [³H] leukotriene B₄ (LTB₄) binding to pig neutrophil membranes with a K_i of 3 μM. 11(Z),14(Z)-Eicosadienoic acid has inflammatory activities.

For research use only. We do not sell to patients.

11(Z),14(Z)-Eicosadienoic acid Chemical Structure

CAS No. : 5598-38-9

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of 11(Z),14(Z)-Eicosadienoic acid:

11,14-Eicosadienoate sodium Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

308.50

Formula

C₂₀H₃₆O₂

CAS No.

5598-38-9

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\CCCCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (405.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 100 mg/mL (324.15 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2415 mL	16.2075 mL	32.4149 mL
5 mM	0.6483 mL	3.2415 mL	6.4830 mL
10 mM	0.3241 mL	1.6207 mL	3.2415 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.10 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (237 KB) HNMR (241 KB) MS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Carballeira NM, et al. Identification of naturally occurring trans, trans delta 5,9 fatty acids from the sponge Plakortis halichondroides. Lipids. 1990 Dec;25(12):835-40. [Content Brief]

[2]. Yagaloff KA, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids. 1995 May;52(5):293-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	3.2415 mL	16.2075 mL	32.4149 mL	81.0373 mL
	5 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	10 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	15 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	20 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	25 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	30 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	40 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	50 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL
	60 mM	0.0540 mL	0.2701 mL	0.5402 mL	1.3506 mL
	80 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0130 mL
	100 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.8104 mL