1. Anti-infection
  2. Bacterial
  3. DprE1-IN-2

DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect.

For research use only. We do not sell to patients.

DprE1-IN-2 Chemical Structure

DprE1-IN-2 Chemical Structure

CAS No. : 1615713-87-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 125 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 180 In-stock
25 mg USD 350 In-stock
50 mg   Get quote  
100 mg   Get quote  

Get it tomorrow December 25 by noon. Order within 5 hrs 11 mins.

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect[1].

IC50 & Target

DprE1[1]

In Vivo

DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c Mice[1]
Dosage: 100 mg/kg
Administration: Oral
Result: Had t1/2 of 0.9 hours and Cmax of 70 μM.
Molecular Weight

368.43

Formula

C19H24N6O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC2=NC=NC(N(C)C)=C2C)C3=CC(C)=CN=C31)NCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (89.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7142 mL 13.5711 mL 27.1422 mL
5 mM 0.5428 mL 2.7142 mL 5.4284 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7142 mL 13.5711 mL 27.1422 mL 67.8555 mL
5 mM 0.5428 mL 2.7142 mL 5.4284 mL 13.5711 mL
10 mM 0.2714 mL 1.3571 mL 2.7142 mL 6.7855 mL
15 mM 0.1809 mL 0.9047 mL 1.8095 mL 4.5237 mL
20 mM 0.1357 mL 0.6786 mL 1.3571 mL 3.3928 mL
25 mM 0.1086 mL 0.5428 mL 1.0857 mL 2.7142 mL
30 mM 0.0905 mL 0.4524 mL 0.9047 mL 2.2618 mL
40 mM 0.0679 mL 0.3393 mL 0.6786 mL 1.6964 mL
50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3571 mL
60 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1309 mL
80 mM 0.0339 mL 0.1696 mL 0.3393 mL 0.8482 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DprE1-IN-2 Related Classifications

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DprE1-IN-2
Cat. No.:
HY-100531
Quantity:
MCE Japan Authorized Agent: