(S,R,S)-AHPC-PEG6-C4-Cl (Synonyms: VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9)

Name: (S,R,S)-AHPC-PEG6-C4-Cl
Brand: MedChemExpress
SKU: HY-103606
Rating: 4.5 (1 reviews)

Cat. No.: HY-103606 Purity: 96.24%: FAQs
Data Sheet SDS COA Handling Instructions

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(S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG6-C4-Cl Chemical Structure

CAS No. : 1835705-59-3

Size	Price	Stock	Quantity
50 mg	USD 344	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

VHL

In Vitro

HaloPROTACs are designed to induce ubiquitylation and degradation of HaloTag7 fusion proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

827.47

Formula

C₄₀H₆₃ClN₄O₁₀S

CAS No.

1835705-59-3

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 100 mg/mL (120.85 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (120.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2085 mL	6.0425 mL	12.0850 mL
5 mM	0.2417 mL	1.2085 mL	2.4170 mL
10 mM	0.1209 mL	0.6043 mL	1.2085 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 96.24%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (244 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)

References

[1]. Tovell H, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019 May 17;14(5):882-892. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	1.2085 mL	6.0425 mL	12.0850 mL	30.2126 mL
	5 mM	0.2417 mL	1.2085 mL	2.4170 mL	6.0425 mL
	10 mM	0.1209 mL	0.6043 mL	1.2085 mL	3.0213 mL
	15 mM	0.0806 mL	0.4028 mL	0.8057 mL	2.0142 mL
	20 mM	0.0604 mL	0.3021 mL	0.6043 mL	1.5106 mL
	25 mM	0.0483 mL	0.2417 mL	0.4834 mL	1.2085 mL
	30 mM	0.0403 mL	0.2014 mL	0.4028 mL	1.0071 mL
	40 mM	0.0302 mL	0.1511 mL	0.3021 mL	0.7553 mL
	50 mM	0.0242 mL	0.1209 mL	0.2417 mL	0.6043 mL
	60 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.5035 mL
	80 mM	0.0151 mL	0.0755 mL	0.1511 mL	0.3777 mL
	100 mM	0.0121 mL	0.0604 mL	0.1209 mL	0.3021 mL

(S,R,S)-AHPC-PEG6-C4-Cl Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG6-C4-Cl1835705-59-3VH032-PEG6-C4-Cl VHL Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 9E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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(S,R,S)-AHPC-PEG6-C4-Cl (Synonyms: VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9)

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Biological Activity

Purity & Documentation

References

Customer Review

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Complete Stock Solution Preparation Table

(S,R,S)-AHPC-PEG6-C4-Cl Related Classifications

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