2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-5

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

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EGFR-IN-5 Chemical Structure

EGFR-IN-5 Chemical Structure

CAS No. : 2225887-26-1

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10 mM * 1 mL in DMSO USD 402 Ask For Quote & Lead Time
Solid
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10 mg USD 510 Ask For Quote & Lead Time
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EGFR-IN-5 Related Antibodies

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Description

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

IC50 & Target[1]

EGFR

10.4 nM (IC50)

EGFRL858R

1.1 nM (IC50)

EGFRL858R/T790M

34 nM (IC50)

EGFRL858R/T790M/C797S

7.2 nM (IC50)

Molecular Weight

571.69

Formula

C31H38FN9O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC(CC1)CCN1C2=NC(NC3=CC=C(F)C=C3)=NC(C=N4)=C2C=C4NC5=NC=C(N6CCC(N(C)C)CC6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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EGFR-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-52225887-26-1EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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