2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Topoisomerase DNA/RNA Synthesis Antibiotic
  4. Garenoxacin

Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Garenoxacin Mesylate hydrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Garenoxacin Chemical Structure

Garenoxacin Chemical Structure

CAS No. : 194804-75-6

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Garenoxacin Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms[1].

IC50 & Target[2]

Quinolone

 

Gyrase

1.25 μg/mL (IC50)

TOPO IV

1.5-2.5 μg/mL (IC50)

In Vitro

Garenoxacin (BMS284756) (0-8 days) inhibits mycoplasmas and ureaplasmas with MIC90s ≤0.25 μg/mL against tested strains[1].
Garenoxacin (48 h) inhibits S. aureus wild type and mutants with MICs of 0.0128-4.0 μg/mL[2].
Garenoxacin inhibits topoisomerase IV and gyrase from S. aureus with IC50s of 1.25 to 2.5 and 1.25 μg/mL, respectively[2].
Garenoxacin has a low propensity for selective enrichment of fluoroquinolone-resistant mutants among ciprofloxacin-susceptible isolates of S. aureus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Garenoxacin Related Antibodies

Cell Viability Assay[1]

Cell Line: M. pneumonia, M. fermentans, M. hominis and Ureaplasma spp.
Concentration:
Incubation Time: 24 h for Ureaplasma spp., 48 h for M. hominis, 4 to 8 days for M. pneumonia
Result: Showed inhibition with MIC90s of 0.031 μg/mL, ≤0.008 μg/mL, ≤0.008 μg/mL and 0.25 μg/mL against M. pneumonia, M. fermentans, M. hominis and Ureaplasma spp. strains, respectively.
In Vivo

Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumonia infection[4].
Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice with S. pneumonia infection[4].
Dosage: 12.5, 25 and 50 mg/kg
Administration: Subcutaneous injection, once
Result: Significantly improved the survival rate.
Molecular Weight

426.41

Formula

C23H20F2N2O4
CAS No.
SMILES

O=C(C1=CN(C2CC2)C3=C(C=CC(C4=CC5=C([C@@H](C)NC5)C=C4)=C3OC(F)F)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Garenoxacin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garenoxacin194804-75-6BMS284756BMS 284756BMS-284756BacterialTopoisomeraseDNA/RNA SynthesisAntibiotictopoisomerase IVgyraseS. aureusmycoplasmasureaplasmasSwiss miceS. pneumoniaInhibitorinhibitorinhibit

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