2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Indoleamine 2,3-Dioxygenase (IDO) HDAC
  4. IDO1 and HDAC1 Inhibitor

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively.

For research use only. We do not sell to patients.

IDO1 and HDAC1 Inhibitor Chemical Structure

IDO1 and HDAC1 Inhibitor Chemical Structure

CAS No. : 2227044-16-6

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IDO1 and HDAC1 Inhibitor Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

View All HDAC Isoform Specific Products:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively[1].

IC50 & Target[1]

IDO1

69.0 nM (IC50)

HDAC1

66.5 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 EC50
0.17 μM
Compound: 83
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
A549 IC50
16.73 μM
Compound: 10
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
CT26 IC50
59.84 μM
Compound: 10
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse CT26 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HCT-116 EC50
5.1 μM
Compound: 83
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
HCT-116 IC50
5.12 μM
Compound: 10
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
HT-29 IC50
11.71 μM
Compound: 10
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
Lewis lung carcinoma cell line IC50
17.62 μM
Compound: 10
Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse LLC cells after 48 hrs by CCK-8 assay
[PMID: 29670692]
Lewis lung carcinoma cell line EC50
18 μM
Compound: 83
Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay
Antiproliferative activity against mouse Lewis lung carcinoma cell line cells assessed as inhibition of cell proliferation by MTT assay
[PMID: 33569941]
Molecular Weight

597.40

Formula

C25H22BrFN8O4
CAS No.
SMILES

BrC1=CC(N/C(C2=NON=C2NCCNC(C3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=N/O)=CC=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IDO1 and HDAC1 Inhibitor Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1 and HDAC1 Inhibitor2227044-16-6Indoleamine 2,3-Dioxygenase (IDO)HDACHistone deacetylasesInhibitorinhibitorinhibit

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