2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-701324

L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity.

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L-701324 Chemical Structure

L-701324 Chemical Structure

CAS No. : 142326-59-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 78 In-stock
Solution
10 mM * 1 mL in DMSO USD 78 In-stock
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5 mg USD 71 In-stock
10 mg USD 115 In-stock
50 mg USD 335 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity[1][2][3].

IC50 & Target

NMDA Receptor

 

In Vivo

L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice[1].
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; daily, for 2 weeks
Result: Reduced the immobility of C57BL/6 J mice.
Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model: Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model: Male Sprague-Dawley rats (280-300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: Oral administration; once
Result: Increased in the percentage of time spent in the open arm in a dose-dependent.
Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
Molecular Weight

363.79

Formula

C21H14ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (93.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7488 mL 13.7442 mL 27.4884 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.92%

COA (247 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7488 mL 13.7442 mL 27.4884 mL 68.7210 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL 13.7442 mL
10 mM 0.2749 mL 1.3744 mL 2.7488 mL 6.8721 mL
15 mM 0.1833 mL 0.9163 mL 1.8326 mL 4.5814 mL
20 mM 0.1374 mL 0.6872 mL 1.3744 mL 3.4360 mL
25 mM 0.1100 mL 0.5498 mL 1.0995 mL 2.7488 mL
30 mM 0.0916 mL 0.4581 mL 0.9163 mL 2.2907 mL
40 mM 0.0687 mL 0.3436 mL 0.6872 mL 1.7180 mL
50 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3744 mL
60 mM 0.0458 mL 0.2291 mL 0.4581 mL 1.1453 mL
80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8590 mL
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L-701324 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-701324142326-59-8L701324L 701324iGluRIonotropic glutamate receptorsglycine B binding siteantidepressantbrain membranestail suspension testforced swim testchronic unpredictable mild stressInhibitorinhibitorinhibit

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