2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Endogenous Metabolite Reactive Oxygen Species Ferroptosis
  4. L-Glutathione reduced

L-Glutathione reduced  (Synonyms: GSH; γ-L-Glutamyl-L-cysteinyl-glycine)

Cat. No.: HY-D0187 Purity: 99.87%
SDS COA Handling Instructions

Molarity Calculator

L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

L-Glutathione reduced Chemical Structure

L-Glutathione reduced Chemical Structure

CAS No. : 70-18-8

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1 g USD 40 In-stock
5 g USD 50 In-stock
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Based on 29 publication(s) in Google Scholar

Other Forms of L-Glutathione reduced:

L-Glutathione reduced Related Antibodies

Top Publications Citing Use of Products

29 Publications Citing Use of MCE L-Glutathione reduced

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
KB 3-1 IC50
> 20 mM
Compound: GSH
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
[PMID: 21657271]
KB-V1 IC50
> 20 mM
Compound: GSH
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
[PMID: 21657271]
In Vitro

L-Glutathione reduced is a non-protein thiol widely exists in living cells. L-Glutathione reduced plays important biological functions in the organism, including protein and DNA synthesis, enzyme activity, metabolism and cell protection. L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutathione reduced Related Antibodies
Molecular Weight

307.32

Formula

C10H17N3O6S
CAS No.
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (203.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2539 mL 16.2697 mL 32.5394 mL
5 mM 0.6508 mL 3.2539 mL 6.5079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (325.39 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

SDS (394 KB)

COA (244 KB) RP-HPLC (246 KB) MS (67 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2539 mL 16.2697 mL 32.5394 mL 81.3484 mL
5 mM 0.6508 mL 3.2539 mL 6.5079 mL 16.2697 mL
10 mM 0.3254 mL 1.6270 mL 3.2539 mL 8.1348 mL
15 mM 0.2169 mL 1.0846 mL 2.1693 mL 5.4232 mL
20 mM 0.1627 mL 0.8135 mL 1.6270 mL 4.0674 mL
25 mM 0.1302 mL 0.6508 mL 1.3016 mL 3.2539 mL
30 mM 0.1085 mL 0.5423 mL 1.0846 mL 2.7116 mL
40 mM 0.0813 mL 0.4067 mL 0.8135 mL 2.0337 mL
50 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6270 mL
60 mM 0.0542 mL 0.2712 mL 0.5423 mL 1.3558 mL
80 mM 0.0407 mL 0.2034 mL 0.4067 mL 1.0169 mL
100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8135 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutathione reduced Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutathione reduced70-18-8GSH γ-L-Glutamyl-L-cysteinyl-glycineEndogenous MetaboliteReactive Oxygen SpeciesFerroptosisInhibitorinhibitorinhibit

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