2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Tyrosine

L-Tyrosine  (Synonyms: Tyrosine)

Cat. No.: HY-N0473 Purity: 99.63%
COA Handling Instructions

Molarity Calculator

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

For research use only. We do not sell to patients.

L-Tyrosine Chemical Structure

L-Tyrosine Chemical Structure

CAS No. : 60-18-4

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Based on 3 publication(s) in Google Scholar

Other Forms of L-Tyrosine:

L-Tyrosine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1-4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0-4.0 mM) following treatment with L-Tyrosine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Tyrosine Related Antibodies
In Vivo

The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

181.19

Formula

C9H11NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CC=C(C=C1)O)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (275.95 mM; Need ultrasonic)

0.1 M HCL : 25 mg/mL (137.98 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5191 mL 27.5953 mL 55.1907 mL
5 mM 1.1038 mL 5.5191 mL 11.0381 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 40 mg/mL (220.76 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

  • Protocol 2

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 40 mg/mL (220.76 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

COA (245 KB) LCMS (259 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References
Kinase Assay
[1]

Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II–III and IV are evaluated[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M HCL / 1M HCl 1 mM 5.5191 mL 27.5953 mL 55.1907 mL 137.9767 mL
5 mM 1.1038 mL 5.5191 mL 11.0381 mL 27.5953 mL
10 mM 0.5519 mL 2.7595 mL 5.5191 mL 13.7977 mL
15 mM 0.3679 mL 1.8397 mL 3.6794 mL 9.1984 mL
20 mM 0.2760 mL 1.3798 mL 2.7595 mL 6.8988 mL
25 mM 0.2208 mL 1.1038 mL 2.2076 mL 5.5191 mL
30 mM 0.1840 mL 0.9198 mL 1.8397 mL 4.5992 mL
40 mM 0.1380 mL 0.6899 mL 1.3798 mL 3.4494 mL
50 mM 0.1104 mL 0.5519 mL 1.1038 mL 2.7595 mL
60 mM 0.0920 mL 0.4599 mL 0.9198 mL 2.2996 mL
80 mM 0.0690 mL 0.3449 mL 0.6899 mL 1.7247 mL
100 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3798 mL
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L-Tyrosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Tyrosine60-18-4TyrosineEndogenous MetaboliteInhibitorinhibitorinhibit

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