LAS-31180 

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC₅₀ of 1.2 mumol/L) and in isolated guinea-pig working hearts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

252.29

C₁₁H₁₂N₂O₃S

137338-43-3

CS(=O)(NC1=CN(C)C2=C(C=CC=C2)C1=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.. . . . .  [Content Brief]

  [2]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.