LAS-31180

Cat. No.: HY-101811: FAQs
Data Sheet Handling Instructions

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LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

For research use only. We do not sell to patients.

LAS-31180 Chemical Structure

CAS No. : 137338-43-3

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Biological Activity
Purity & Documentation
References
Customer Review

Description	LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
In Vitro	LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC₅₀ of 1.2 mumol/L) and in isolated guinea-pig working hearts^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. LAS-31180 Related Antibodies
In Vivo	In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	252.29
Formula	C₁₁H₁₂N₂O₃S
CAS No.	137338-43-3
SMILES	CS(=O)(NC1=CN(C)C2=C(C=CC=C2)C1=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.. . . . . [Content Brief] [2]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.

LAS-31180 Related Classifications

Cardiovascular Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAS-31180137338-43-3LAS31180LAS 31180Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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