(2-Chloropyridin-4-yl)methanamine hydrochloride

Name: (2-Chloropyridin-4-yl)methanamine hydrochloride
Brand: MedChemExpress
SKU: HY-101771A
Rating: 5.0 (4 reviews)

Cat. No.: HY-101771A Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

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(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC₅₀ of 126 nM.

For research use only. We do not sell to patients.

(2-Chloropyridin-4-yl)methanamine hydrochloride Chemical Structure

CAS No. : 916210-98-5

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10 mM * 1 mL in DMSO ready for reconstitution	USD 92	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 92	In-stock	Estimated Time of Arrival: December 31
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100 mg	USD 84	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

4 Publications Citing Use of MCE (2-Chloropyridin-4-yl)methanamine hydrochloride

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC₅₀ of 126 nM.

IC₅₀ & Target

IC50: 126 nM (LOXL2)^[1]

In Vitro

(2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC₅₀ of 1.45 μM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC₅₀=190 nM) over LOX+BSA (IC₅₀=5.91 μM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 μM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC₅₀ is more than 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

179.05

Formula

C₆H₈Cl₂N₂

CAS No.

916210-98-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.ClC1=NC=CC(CN)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (279.25 mM)

DMSO : ≥ 33 mg/mL (184.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5850 mL	27.9252 mL	55.8503 mL
5 mM	1.1170 mL	5.5850 mL	11.1701 mL
10 mM	0.5585 mL	2.7925 mL	5.5850 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (558.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (246 KB) HNMR (251 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.5850 mL	27.9252 mL	55.8503 mL	139.6258 mL
	5 mM	1.1170 mL	5.5850 mL	11.1701 mL	27.9252 mL
	10 mM	0.5585 mL	2.7925 mL	5.5850 mL	13.9626 mL
	15 mM	0.3723 mL	1.8617 mL	3.7234 mL	9.3084 mL
	20 mM	0.2793 mL	1.3963 mL	2.7925 mL	6.9813 mL
	25 mM	0.2234 mL	1.1170 mL	2.2340 mL	5.5850 mL
	30 mM	0.1862 mL	0.9308 mL	1.8617 mL	4.6542 mL
	40 mM	0.1396 mL	0.6981 mL	1.3963 mL	3.4906 mL
	50 mM	0.1117 mL	0.5585 mL	1.1170 mL	2.7925 mL
	60 mM	0.0931 mL	0.4654 mL	0.9308 mL	2.3271 mL
	80 mM	0.0698 mL	0.3491 mL	0.6981 mL	1.7453 mL
	100 mM	0.0559 mL	0.2793 mL	0.5585 mL	1.3963 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.