1. Neuronal Signaling
  2. Monoamine Oxidase
  3. (2-Chloropyridin-4-yl)methanamine hydrochloride

(2-Chloropyridin-4-yl)methanamine hydrochloride 

Cat. No.: HY-101771A Purity: 99.70%
COA Handling Instructions

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

For research use only. We do not sell to patients.

(2-Chloropyridin-4-yl)methanamine hydrochloride Chemical Structure

(2-Chloropyridin-4-yl)methanamine hydrochloride Chemical Structure

CAS No. : 916210-98-5

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10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

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Description

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

IC50 & Target

IC50: 126 nM (LOXL2)[1]

In Vitro

(2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC50 of 1.45 μM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 μM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 μM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

179.05

Formula

C6H8Cl2N2

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.ClC1=NC=CC(CN)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (279.25 mM)

DMSO : ≥ 33 mg/mL (184.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5850 mL 27.9252 mL 55.8503 mL
5 mM 1.1170 mL 5.5850 mL 11.1701 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (558.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.70%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.5850 mL 27.9252 mL 55.8503 mL 139.6258 mL
5 mM 1.1170 mL 5.5850 mL 11.1701 mL 27.9252 mL
10 mM 0.5585 mL 2.7925 mL 5.5850 mL 13.9626 mL
15 mM 0.3723 mL 1.8617 mL 3.7234 mL 9.3084 mL
20 mM 0.2793 mL 1.3963 mL 2.7925 mL 6.9813 mL
25 mM 0.2234 mL 1.1170 mL 2.2340 mL 5.5850 mL
30 mM 0.1862 mL 0.9308 mL 1.8617 mL 4.6542 mL
40 mM 0.1396 mL 0.6981 mL 1.3963 mL 3.4906 mL
50 mM 0.1117 mL 0.5585 mL 1.1170 mL 2.7925 mL
60 mM 0.0931 mL 0.4654 mL 0.9308 mL 2.3271 mL
80 mM 0.0698 mL 0.3491 mL 0.6981 mL 1.7453 mL
100 mM 0.0559 mL 0.2793 mL 0.5585 mL 1.3963 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(2-Chloropyridin-4-yl)methanamine hydrochloride Related Classifications

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Product Name:
(2-Chloropyridin-4-yl)methanamine hydrochloride
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