2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M40

M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.

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M40 Chemical Structure

M40 Chemical Structure

CAS No. : 143896-17-7

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M40 Related Antibodies

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Description

M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

In Vitro

M40 (1 μM) displaces [mono[125IJodo-Tyr26]galanin from binding sites in the hippocampus, hypothalamus, and spinal cord. M40 has a lower affinity than galanin for all membranes. The IC50 values are 6 nM in the hippocampus, 15 nM in the hypothalamus, 12 nM in the spinal cord, and 3 nM in the insulinoma cells. M40 (1 μM) completely blocks 125I-labeled galanin-binding sites[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M40 Related Antibodies
In Vivo

M40 (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1]
Dosage: 0.1-1 nmol
Administration: Intracisternal injection, single dose
Result: Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29).
Animal Model: Memory impairment induced by galanin in rats model[2]
Dosage: 2-8 nmol
Administration: intraventricular or intrahippocampal, single dose
Result: Blocked the impairment in choice accuracy.
Molecular Weight

1980.31

Formula

C95H146N22O24
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

GWTLNSAGYLLGPPPALALA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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M40 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M40143896-17-7M 40M-40Neuropeptide Y ReceptorNPY receptorSprague-Dawley ratsmemory impairmentalzheimer’s diseaseInhibitorinhibitorinhibit

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