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Results for "

MG132

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13259
    MG-132
    1270+ Cited Publications

    Z-Leu-Leu-Leu-al; MG132

    		 Proteasome Autophagy Apoptosis Cancer
    MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
    MG-132
  • HY-13259D
    MG-132 (negative control)

    		Proteasome Cancer
    MG-132 negative control is the negative control form of MG-132 (HY-13259). MG-132 is a potent proteasome and calpain inhibitor .
    MG-132 (negative control)
  • HY-13259C
    (R)-MG-132
    5+ Cited Publications

    (S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al

    		 Proteasome Cancer
    (R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132 .
    (R)-MG-132
  • HY-111844
    PROTAC RAR Degrader-1

    		PROTACs SNIPERs RAR/RXR Neurological Disease Metabolic Disease Cancer
    PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .
    PROTAC RAR Degrader-1
  • HY-168323
    UP163

    		p97 Others
    UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates .
    UP163
  • HY-N9647
    Dalbinol

    		Wnt β-catenin Apoptosis Cancer
    Dalbinol is a rotenoid compound. Dalbinol can inhibit Wnt/β-catenin signaling pathway and promote β-catenin degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .
    Dalbinol

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