Midodrine hydrochloride (Synonyms: (±)-Midodrine hydrochloride)

Cat. No.: HY-12749A Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Midodrine hydrochloride ((±)-Midodrine hydrochloride) is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.

For research use only. We do not sell to patients.

Midodrine hydrochloride Chemical Structure

CAS No. : 43218-56-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Midodrine hydrochloride:

Midodrine-d₆ hydrochloride Get quote
Midodrine Get quote

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

Biological Activity
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Description

Midodrine hydrochloride ((±)-Midodrine hydrochloride) is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.

IC₅₀ & Target

α adrenergic receptor

Clinical Trial

Molecular Weight

290.74

Formula

C₁₂H₁₉ClN₂O₄

CAS No.

43218-56-0

Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (343.95 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4395 mL	17.1975 mL	34.3950 mL
5 mM	0.6879 mL	3.4395 mL	6.8790 mL
10 mM	0.3439 mL	1.7197 mL	3.4395 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.49%

Select Batch:

Data Sheet (242 KB) SDS (252 KB)

COA (246 KB) HNMR (274 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.4395 mL	17.1975 mL	34.3950 mL	85.9875 mL
	5 mM	0.6879 mL	3.4395 mL	6.8790 mL	17.1975 mL
	10 mM	0.3439 mL	1.7197 mL	3.4395 mL	8.5987 mL
	15 mM	0.2293 mL	1.1465 mL	2.2930 mL	5.7325 mL
	20 mM	0.1720 mL	0.8599 mL	1.7197 mL	4.2994 mL
	25 mM	0.1376 mL	0.6879 mL	1.3758 mL	3.4395 mL
	30 mM	0.1146 mL	0.5732 mL	1.1465 mL	2.8662 mL
	40 mM	0.0860 mL	0.4299 mL	0.8599 mL	2.1497 mL
	50 mM	0.0688 mL	0.3439 mL	0.6879 mL	1.7197 mL
	60 mM	0.0573 mL	0.2866 mL	0.5732 mL	1.4331 mL
	80 mM	0.0430 mL	0.2150 mL	0.4299 mL	1.0748 mL
	100 mM	0.0344 mL	0.1720 mL	0.3439 mL	0.8599 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Midodrine hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midodrine43218-56-0(±)-MidodrineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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