2. NF-κB
  3. NF-κB
  4. N,N-Dimethylacetamide

N,N-Dimethylacetamide  (Synonyms: DMAc)

Cat. No.: HY-W042416 Purity: 99.96%
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N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.

For research use only. We do not sell to patients.

N,N-Dimethylacetamide Chemical Structure

N,N-Dimethylacetamide Chemical Structure

CAS No. : 127-19-5

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Based on 1 publication(s) in Google Scholar

Other Forms of N,N-Dimethylacetamide:

N,N-Dimethylacetamide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N,N-Dimethylacetamide

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Description

N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease[1][2][3].

In Vitro

N,N-Dimethylacetamide (10-1000 μM, 24 h) inhibits the bactericidal activity of macrophages in RAW 264.7 cells[1].
N,N-Dimethylacetamide (0.1-10 mM, 2 h) inhibits Aβ-induced inflammation in microglia cell lines SIM-A9 and HMC3[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-Dimethylacetamide Related Antibodies

Western Blot Analysis[2]

Cell Line: SIM-A9, HMC3
Concentration: 0.1, 1, 10 mM
Incubation Time: 2 h
Result: Diminished iNOS production.
Decreased Aβ42 in a concentration-dependent manner.
Reduced APP and p-APP protein levels at 1 and 10 mM.
Increased IκBα levels in SIM-A9 cells with both 1 mM and 10 mM and in HMC3 cells with 10 mM.
In Vivo

N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, intraperitoneally administered) prevents endotoxin-induced preterm birth in C57BL/6 embryo-day (E) 15.5 mice. And the pups were protected from spontaneous abortion in a dose-dependent manner[1].
N,N-Dimethylacetamide (2.1 g/kg/day, intraperitoneally administered) attenuates the clinical and histological features of DSS-induced colitis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-Triggered PTB and Spontaneous Abortions mice[1]
Dosage: 0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
Administration: i.p. Single dose
Result: Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
Animal Model: DSS-induced colitis in C57Bl/6 mice[3]
Dosage: 2.1 g/kg
Administration: i.p. once a day for four days
Result: Attenuated inflammation, crypt injury and ulceration.
Molecular Weight

87.12

Formula

C4H9NO
CAS No.
Appearance

Liquid (Density: 0.937 g/cm3)

Color

Colorless to light yellow

SMILES

CC(N(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (1147.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.96%

SDS (761 KB)

COA (246 KB) HNMR (112 KB) GC (195 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 11.4784 mL 57.3921 mL 114.7842 mL 286.9605 mL
5 mM 2.2957 mL 11.4784 mL 22.9568 mL 57.3921 mL
10 mM 1.1478 mL 5.7392 mL 11.4784 mL 28.6961 mL
15 mM 0.7652 mL 3.8261 mL 7.6523 mL 19.1307 mL
20 mM 0.5739 mL 2.8696 mL 5.7392 mL 14.3480 mL
25 mM 0.4591 mL 2.2957 mL 4.5914 mL 11.4784 mL
30 mM 0.3826 mL 1.9131 mL 3.8261 mL 9.5654 mL
40 mM 0.2870 mL 1.4348 mL 2.8696 mL 7.1740 mL
50 mM 0.2296 mL 1.1478 mL 2.2957 mL 5.7392 mL
60 mM 0.1913 mL 0.9565 mL 1.9131 mL 4.7827 mL
80 mM 0.1435 mL 0.7174 mL 1.4348 mL 3.5870 mL
100 mM 0.1148 mL 0.5739 mL 1.1478 mL 2.8696 mL
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N,N-Dimethylacetamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N-Dimethylacetamide127-19-5DMAcNF-κBNuclear factor-κBNuclear factor-kappaBDMAAnti-inflammatoryHigh fat dietADDSSSIM-A9HMC3RAW 264.7Inhibitorinhibitorinhibit

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