PGLa

Cat. No.: HY-P0274: FAQs
Data Sheet Handling Instructions

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PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions.

For research use only. We do not sell to patients.

PGLa Chemical Structure

CAS No. : 102068-15-5

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Other Forms of PGLa:

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Biological Activity
Purity & Documentation
References
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Description

PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions^[1].

IC₅₀ & Target

Anti-bacteria^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	> 50.8 μM Compound: PGLa	Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by XTT assay	[PMID: 20086159]

In Vitro

PGLa is a peptide starting with a glycine and ending with a leucine amide^[1].
PGLa is bacteriostatic against both Gram-positive and Gram-negative bacteria with MIC values of 64 and 32 mg/L against S. aureus and E. coli, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

1968.45

Formula

C₈₈H₁₆₂N₂₆O₂₂S

CAS No.

102068-15-5

Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2

Sequence Shortening

GMASKAGAIAGKIAKVALKAL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bechinger B, et al. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb;74(2 Pt 1):981-7. [Content Brief]

[2]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27. [Content Brief]

PGLa Related Classifications

Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGLa102068-15-5BacterialAntibioticantimicrobialpeptidefrogInhibitorinhibitorinhibit

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