2. Anti-infection
  3. HIV
  4. Peptide T

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

For research use only. We do not sell to patients.

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Peptide T Chemical Structure

Peptide T Chemical Structure

CAS No. : 106362-32-7

Size Price Stock Quantity
1 mg USD 100 In-stock
5 mg USD 220 In-stock
10 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Peptide T:

Peptide T Related Antibodies

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

IC50 & Target

CD4, HIV[1]
In Vitro

Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peptide T Related Antibodies
In Vivo

Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

857.86

Formula

C35H55N9O16
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr
Sequence Shortening

ASTTTNYT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (116.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1657 mL 5.8285 mL 11.6569 mL
5 mM 0.2331 mL 1.1657 mL 2.3314 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Cell Assay
[3]

Peripheral blood mononuclear cells are stimulated with PHA (5 mg/mL) along with various concentrations of peptide T (10-6-10-12 M) for 48 h at 37°C. Supernatants are collected and frozen until analysis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats[4]

Peptide T (125, 250, 500, 800 μg) is randomly given subcutaneously to Female Lewis rats aged 6-8 weeks in the hind foot flanks in a final volume of 0.2 mL. Control animals receive the same volume of saline alone[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1657 mL 5.8285 mL 11.6569 mL 29.1423 mL
5 mM 0.2331 mL 1.1657 mL 2.3314 mL 5.8285 mL
10 mM 0.1166 mL 0.5828 mL 1.1657 mL 2.9142 mL
15 mM 0.0777 mL 0.3886 mL 0.7771 mL 1.9428 mL
20 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4571 mL
25 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
30 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.9714 mL
40 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7286 mL
50 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5828 mL
60 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.4857 mL
80 mM 0.0146 mL 0.0729 mL 0.1457 mL 0.3643 mL
100 mM 0.0117 mL 0.0583 mL 0.1166 mL 0.2914 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Peptide T Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peptide T106362-32-7HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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