2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Pipecolic acid

L-Pipecolic acid  (Synonyms: H-HoPro-OH)

Cat. No.: HY-W012734 Purity: ≥98.0%
SDS COA Handling Instructions Technical Support

L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases.

For research use only. We do not sell to patients.

L-Pipecolic acid Chemical Structure

L-Pipecolic acid Chemical Structure

CAS No. : 3105-95-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Pipecolic acid:

L-Pipecolic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L-Pipecolic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-Pipecolic acid (100 μM, 30 minutes) significantly increases the rate of protein synthesis in C2C12 myotubes, showing stronger effects than L-lysine (HY-N0469) [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Pipecolic acid Related Antibodies

Western Blot Analysis[3]

Cell Line: C2C12 myotubes (skeletal muscle, C2C12 mouse)
Concentration: 100 μM
Incubation Time: 30 min
Result: Significantly suppressed the rate of protein degradation and autophagy activity, with no effect on the ubiquitin-proteasomal system.
In Vivo

L-Pipecolic acid (250 mg/kg, p.o., once a day, for 7 days) improves intestinal motility in Loperamide (HY-156131)-induced constipated mice and increases 5-HT levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Loperamide (HY-156131)-induced constipation model in C57BL/6 mice[2]
Dosage: 250 mg/kg
Administration: Oral gavage (p.o.), once a day, for 7 consecutive days
Result: Showed significantly increased fecal water content, improved intestinal transit rate, shortened first black stool defecation time, and significantly increased 5-HT levels.
Molecular Weight

129.16

Formula

C6H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1NCCCC1)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (774.24 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.74 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.7424 mL 38.7120 mL 77.4240 mL
5 mM 1.5485 mL 7.7424 mL 15.4848 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (774.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.7424 mL 38.7120 mL 77.4240 mL 193.5599 mL
5 mM 1.5485 mL 7.7424 mL 15.4848 mL 38.7120 mL
H2O 10 mM 0.7742 mL 3.8712 mL 7.7424 mL 19.3560 mL
15 mM 0.5162 mL 2.5808 mL 5.1616 mL 12.9040 mL
20 mM 0.3871 mL 1.9356 mL 3.8712 mL 9.6780 mL
25 mM 0.3097 mL 1.5485 mL 3.0970 mL 7.7424 mL
30 mM 0.2581 mL 1.2904 mL 2.5808 mL 6.4520 mL
40 mM 0.1936 mL 0.9678 mL 1.9356 mL 4.8390 mL
50 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
60 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2260 mL
80 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4195 mL
100 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Pipecolic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Pipecolic acid3105-95-1H-HoPro-OHEndogenous MetaboliteC2C12 myotubesC2C12 mouseconstipationmetabolic disordersmuscle disordersintestinal diseasesInhibitorinhibitorinhibit

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