Piperazine citrate  (Synonyms: 1,4-Diazacyclohexane citrate)

Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist^[1]. Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities^[2].

Piperazine citrate is a promising scaffold with analgesic and anti-inflammatory potential^[3].
Piperazine citrate is a key substructure for antidepressants^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

321.33

C₆H₈O₇.3/2 C₄H₁₀N₂

144-29-6

Solid

White to off-white

O=C(CC(C(O)=O)(O)CC(O)=O)O.O=C(CC(C(O)=O)(O)CC(O)=O)O.N1CCNCC1.N2CCNCC2.N3CCNCC3

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Lovell RA. Ivermectin and piperazine toxicoses in dogs and cats. Vet Clin North Am Small Anim Pract. 1990;20(2):453-468.  [Content Brief]

  [2]. Girase PS, et al. An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review. Eur J Med Chem. 2021;210:112967.  [Content Brief]

  [3]. Jain A, et al. Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential. Drug Res (Stuttg). 2021;71(2):62-72.  [Content Brief]

  [4]. Kumar RR, et al. Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships. ChemMedChem. 2021;16(12):1878-1901.  [Content Brief]