Search Result
Results for "
Piperazine
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-130587
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Piperazine sultosylate; A-585
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Others
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Metabolic Disease
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Sultosilic acid piperazine salt (Piperazine sultosylate; A-585) is a lipid-lowering agent. Sultosilic acid piperazine salt modifies the blood lipids levels, reduces platelet adhesiveness without promoting peroxisomal activity of hepatocytes or producing other adverse side-effects .
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- HY-100887
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Ferroptosis
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Cancer
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Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research .
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- HY-B2186
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Parasite
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Infection
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Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
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- HY-17599
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1,4-Diazacyclohexane citrate
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GABA Receptor
Parasite
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Infection
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Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist . Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities .
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- HY-B1361
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Piperazine estrone sulfate; Estrone sulfate Piperazine salt
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Estrogen Receptor/ERR
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Endocrinology
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Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.
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- HY-B2186R
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Parasite
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Infection
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Piperazine adipate (Standard) is the analytical standard of Piperazine adipate. This product is intended for research and analytical applications. Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
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- HY-161444
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PROTAC Linkers
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Others
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Piperazine-acetyl-PIP-AcOH is a PROTAC linker. Piperazine-acetyl-PIP-AcOH can be used for PROTAC synthesis .
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- HY-W560922
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PROTAC Linkers
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Cancer
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Piperazine-Ac-OMe is a PROTAC linker. Piperazine-Ac-OMe can be used in the synthesis of PROTAC SMARCA2/4-degrader-32 (HY-159459) .
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- HY-159592
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PROTAC Linkers
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Cancer
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Piperazine-Pyrimidine-Cyclohexane-COOEt is a PROTAC linker. Piperazine-Pyrimidine-Cyclohexane-COOEt can be used in the synthesis of PROTAC SMARCA2/4-degrader-1 (HY-159452) .
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- HY-148830
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Liposome
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Others
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Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-W008813
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- HY-44432
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ABT-263-Piperazine
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Bcl-2 Family
Ligands for Target Protein for PROTAC
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Cancer
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Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604) with anti-tumor activity .
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- HY-161201
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-piperazine-pyrimidine-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-pyrimidine-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-B1505A
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- HY-W438378
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HMPG Piperazine
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Biochemical Assay Reagents
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Others
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4-Hydroxy-3-methoxyphenylglycol piperazine (HMPG piperazine) is a salt of HMPG combined with piperazine. HMPG is a metabolite of adrenaline and norepinephrine and is an important marker of catecholamine hormone metabolism in the body. 4-Hydroxy-3-methoxyphenylglycol piperazine is used as a standard in clinical laboratories to accurately measure the HMPG content in urine .
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- HY-W834174
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- HY-157760
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN proteins and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-W259932
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Ligands for E3 Ligase
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Cancer
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Lenalidomide 5'-piperazine is a functionalized cerebellar ligand for PROTAC development that binds an E3 ligand to terminal piperazine for subsequent chemical reactions to produce a protein deactivator with a rigid linker .
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- HY-W715044
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- HY-163233
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-132971
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Molecular Glues
Ligands for E3 Ligase
Autophagy
Apoptosis
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Cancer
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Thalidomide-piperazine hydrochloride has the potential for the research of leprosy and multiple myeloma. Thalidomide-piperazine hydrochloride used as a tool in developmental biology leads to important discoveries in the biochemical pathways of limb development .
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- HY-W797383
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- HY-160244
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Ligands for E3 Ligase
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Cancer
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Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
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- HY-138783A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
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- HY-W002603
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Biochemical Assay Reagents
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Others
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Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-157759
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN proteins and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-148834
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- HY-W009681
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5-HT Receptor
Serotonin Transporter
Drug Intermediate
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Infection
Neurological Disease
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1-(2-Methoxyphenyl)piperazine hydrochloride is a key agent intermediate of antipsychotics with high affinity to the serotonin receptors and 5-HT, which can be used to synthesize the intestinal worm-repellent agents Piperazine phosphate (HY-B0912C) and Piperazine citrate (HY-17599), as well as Fluphenazine (HY-119980), dihydrochloride, Rifampicin (HY-B0272) .
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- HY-20797
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- HY-163223
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-Y0889
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Others
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Metabolic Disease
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1-(2,3-Dichlorphenyl)piperazine is a potent DHCR7 inhibitor with the activity of inhibiting cholesterol biosynthesis. 1-(2,3-Dichlorphenyl)piperazine is often used in biological research to evaluate the function of cholesterol biosynthesis pathway. The application of 1-(2,3-Dichlorphenyl)piperazine is of great significance for understanding diseases related to cholesterol biosynthesis .
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- HY-163210
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Ligands for E3 Ligase
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Cancer
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Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC .
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- HY-169376
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PROTAC Linkers
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Cancer
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Boc-piperazine-C13-OTs is a PROTAC linker. Boc-piperazine-C13-OTs can be used to synthesize NC-R17 (HY-155075) .
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- HY-157566
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Ligands for E3 Ligase
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Cancer
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Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated .
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- HY-157758
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker . (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-163239
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Ligands for E3 Ligase
Autophagy
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Cancer
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(R)-Thalidomide-piperazine-pyrrolidineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (R)-Thalidomide-piperazine-pyrrolidineethanol can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-134982
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- HY-W904851
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PROTAC Linkers
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Cancer
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Boc-Piperidine-piperazine-Cbz is a PROTAC linker that can be used in the synthesis of ZLC491 (HY-168162) .
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- HY-W840791
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PROTAC Linkers
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Cancer
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1-(2-Bromoethyl)piperazine is a PROTAC linker can be used in the synthesis of PROTAC (HY-168634) .
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- HY-145766
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Others
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Others
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Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is an active compound .
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- HY-138783
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- HY-W013249
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PROTAC Linkers
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Cancer
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Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229) .
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- HY-41939
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Biochemical Assay Reagents
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Others
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1-(2-Hydroxyethyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W001978
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Biochemical Assay Reagents
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Others
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1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-168217
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-piperazine-piperidine-2-F-Ph-CHO is a E3 ligase ligand-linker conjugate, which is consisted of a Thalidomide (HY-14658) and a linker Boc-Piperazine-piperidine-2-F-Ph-CHO (HY-168218). Thalidomide-piperazine-piperidine-2-F-Ph-CHO is utilized for synthesis of PROTAC molecule YDR1 (HY-168215) .
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- HY-168224
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PROTACs
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Cancer
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Thalidomide-PEG1-piperazine-2-F-Ph-CHO is an E3 ligase ligand-linker conjugate, used for the synthesis of YD54 (HY-168221) .
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- HY-168272
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(3S)Lenalidomide-piperazine-C-piperidine is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). (3S)Lenalidomide-piperazine-C-piperidine can be used to synthesize PROTAC PROTAC ER Degrader-11 (HY-168270) .
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- HY-145755
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Others
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Others
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Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .
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- HY-30105
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PROTAC Linkers
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Cancer
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N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
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- HY-131184
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PROTAC Linkers
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Inflammation/Immunology
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N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
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- HY-134983
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- HY-131706A
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Trk Receptor
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Cancer
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GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1 .
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- HY-161193
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-piperazine-(R)-C-pyrrolidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-(R)-C-pyrrolidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161195
-
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Ligands for E3 Ligase
Autophagy
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Cancer
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Deoxy-thalidomide-piperidine-C-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161200
-
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-piperazine-C-azetidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-C-azetidine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-168197
-
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PROTACs
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Cancer
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Thalidomide-F-piperidine-piperazine-Cbz Conjugate 110 is a conjugate of E3 ligase and linker for the synthesis of CDK12/13 PROTAC degrader (HY-168162) .
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- HY-W145436
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- HY-138780
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-
- HY-138781
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- HY-138782
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- HY-168223
-
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PROTAC Linkers
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Cancer
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Boc-Piperazine-2-F-Ph-CHO (Compound 2) is a PROTAC linker, used for the synthesis of YD54 (HY-168221) .
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- HY-W001990
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1-(Pyridin-2-yl)Piperazine
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Biochemical Assay Reagents
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Others
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1-(2-Pyridyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-168239
-
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates). Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph can be used for the synthesis of PROTAC SMARCA2 degrader-28 (HY-168236) .
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- HY-169377
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- HY-40041
-
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Biochemical Assay Reagents
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Others
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(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-161184
-
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Ligands for E3 Ligase
Autophagy
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Cancer
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Deoxy-thalidomide-piperidine-C-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161203
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-azetidine-piperazine-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-piperazine-C2-O-C-boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-168218
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PROTAC Linkers
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Cancer
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Boc-Piperazine-piperidine-2-F-Ph-CHO is a PROTAC linker that can be used in the synthesis of YDR1 (HY-168215) .
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- HY-161445
-
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules .
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- HY-138788
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- HY-138789
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- HY-138787
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- HY-159974
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Me-SJ46411-PEG1-Piperazine-Boc is a conjugate of E3 ubiquitin ligase and PROTAC linker, which can be used for the synthesis of PROTAC molecules. For example, Me-SJ46411-PEG1-Piperazine-Boc combined with target protein ligand (+)-JQ-1 (HY-13030) can be used to synthesize the selective BRD3 PROTAC degrader SJ46420 (HY-168635). .
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- HY-169991
-
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PROTAC Linkers
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Others
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1-(3,3-Difluoro-4-piperidinyl)piperazine is the PROTAC linker of CFT8634 (HY-145925B) and can be used in the synthesis of PROTACs .
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- HY-120220
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A-20968; Ancyte
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Others
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Cancer
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Piposulfan (Ancyte) is a methanesulfonate, alkylating derivative of piperazine. Piposulfan has potential antineoplastic activity. Piposulfan can be used for the research of cancer .
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- HY-161191
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-azetidine-piperazine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-piperazine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-138788A
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- HY-138789A
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- HY-131386A
-
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Target Protein Ligand-Linker Conjugates
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Cancer
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BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
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- HY-133702
-
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PROTAC Linkers
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Cancer
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Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor) .
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- HY-163225
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-159490
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- HY-131386
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Target Protein Ligand-Linker Conjugates
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Cancer
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BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
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- HY-163221
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-125705
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Herqueline A
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Influenza Virus
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Infection
Cardiovascular Disease
|
|
Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
|
-
- HY-131186
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-amido-C3-piperazine-N-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
|
-
- HY-66010A
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
Cinepazide is a piperazine derivative and acts as a weak calcium channel blocker. Cinepazide is a potent vasodilator and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain infarct et. al .
|
-
- HY-W013376
-
|
1-(Diphenylmethyl)Piperazine; 1-BenzhydrylPiperazine
|
Antibiotic
Bacterial
Penicillin-binding protein (PBP)
|
Infection
Cancer
|
|
Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents .
|
-
- HY-66010
-
|
MD-67350
|
Calcium Channel
|
Cardiovascular Disease
|
|
Cinepazide Maleate (MD-67350) is a piperazine derivative and acts as a weak calcium channel blocker. Cinepazide Maleate is a potent vasodilator and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain infarct et. al .
|
-
- HY-163231
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-157749
-
|
|
Ligands for E3 Ligase
Autophagy
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C (CH3)3 is a synthetic E3 ligase ligand-Linker conjugate. Thalidomide-piperazine-(S)-Ch2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 includes Thalidomide-based cereblon ligands and linkers. Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 can be used to synthesize PROTAC BET .
|
-
- HY-B0349
-
|
Meclozine dihydrochloride
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .
|
-
- HY-B0349A
-
|
Meclozine
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Inflammation/Immunology
|
|
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease .
|
-
- HY-B0349B
-
|
Meclozine dihydrochloride monohydrate
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Inflammation/Immunology
|
|
Meclizine (Meclozine) dihydrochloride monohydrate, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride monohydrate is an effective anti-motion sickness agent. Meclizine dihydrochloride monohydrate crosses the blood-brain barrier. Meclizine dihydrochloride monohydrate is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride monohydrate can be used for the research of polyQ toxicity disorders, such as Huntington's disease .
|
-
- HY-157920
-
|
N-Biotinyl-N'-[2-(N-maleimido)ethyl]Piperazine
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
|
-
- HY-B0349R
-
|
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Meclizine (dihydrochloride) (Standard) is the analytical standard of Meclizine (dihydrochloride). This product is intended for research and analytical applications. Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .
|
-
- HY-130837
-
|
|
Bacterial
|
Infection
|
|
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL .
|
-
- HY-130838
-
|
|
Bacterial
|
Infection
|
|
JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL .
|
-
- HY-130836
-
|
|
Bacterial
|
Infection
|
|
LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .
|
-
- HY-123229
-
-
- HY-W031620
-
|
|
Sodium Channel
|
Neurological Disease
|
|
VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research .
|
-
- HY-B1397
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness .
|
-
- HY-B1397A
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness .
|
-
- HY-B1397C
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
Cyclizine hydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine hydrochloride can be used for the research of nausea, vomiting, and dizziness .
|
-
- HY-159494
-
|
|
PROTACs
Epoxide Hydrolase
|
Metabolic Disease
|
|
sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174)) .
|
-
- HY-W956235
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(piperazin-1-yl)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is an E3 ligase ligand-linker conjugate.
|
-
- HY-114719
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
A 854777 is a homologous piperazine derivative with anti-inflammatory activity. A 854777 has non-classical immunosuppressive properties. A 854777 can be used to suppress diseases associated with inflammation .
|
-
- HY-W414406
-
|
|
Biochemical Assay Reagents
|
Others
|
|
CABS is a zwitterionic piperazine buffer reagent, which can be used as a buffer reagent for wetting agents, pesticide emulsifiers, and dispersants, and has been used in fluorescent dyeing applications .
|
-
- HY-B1397B
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness .
|
-
- HY-A0198
-
|
U 41123
|
GABA Receptor
|
Neurological Disease
|
|
Adinazolam (U 41123) is a benzodiazepine agonist. Adinazolam, a triazolobenzodiazepine, has dual anxiolytic and antidepressant activities .
|
-
- HY-A0198A
-
|
U 41123F mesylate
|
GABA Receptor
|
Neurological Disease
|
|
Adinazolam mesylate (U 41123) is a benzodiazepine agonist. Adinazolam mesylate, a triazolobenzodiazepine, has dual anxiolytic and antidepressant activities .
|
-
- HY-112538
-
|
1-NP hydrochloride; 1-NaphthylPiperazine hydrochloride
|
5-HT Receptor
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis .
|
-
- HY-118402
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis .
|
-
- HY-157588
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
E3 ligase Ligand-Linker Conjugate 30 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 30 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-162144
-
|
|
Bacterial
|
Infection
|
|
BDM91288 is an orally active AcrB efflux pump inhibitor of pyridinium piperazine. BDM91288 can enhance the in vivo efficacy of levofloxacin (HY-B0330) in the treatment of Klebsiella pneumoniae pulmonary infection in mouse models .
|
-
- HY-16398
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
|
-
- HY-W008865
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
|
-
- HY-110191
-
|
|
mGluR
|
Neurological Disease
Cancer
|
|
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM .
|
-
- HY-144320
-
|
|
HBV
|
Infection
|
|
HBV-IN-17 (compound 8) is a potent HBV capsid assembly modulator with an EC50 of 511 nM .
|
-
- HY-155146
-
|
|
Necroptosis
|
Cancer
|
|
Anticancer agent 146 (compound 1.19) is a necroptosis inducer. Anticancer agent 146 has anti-tumor efficacy in the mouse MDA-MB-231 xenograft model .
|
-
- HY-157919
-
|
N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]Piperazine, hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
|
-
- HY-148042
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect .
|
-
- HY-160552
-
|
|
Liposome
|
Others
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
-
- HY-W395779
-
|
|
Filovirus
|
Infection
|
|
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .
|
-
- HY-149917
-
|
|
PROTACs
Itk
|
Cancer
|
|
ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice), with good plasma exposure levels. ITK degrader 1 induces rapid, and prolonged ITK degradation and suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibodyin vivo. ITK degrader 1 consists of target protein ligand (red part) ITK ligand 1 (HY-168387), PROTAC linker (black part) Piperidine-C2-piperazine-Boc (HY-168388) and E3 ubiquitinase ligand (blue part) Thalidomide 5-fluoride (HY-W087383). E3 ubiquitinase and PROTAC linker can form Thalidomide-piperidine-C2-piperazine-Boc (HY-168389) .
|
-
- HY-146116
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .
|
-
- HY-151959
-
|
|
FXR
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .
|
-
- HY-159973
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Me-SJ46411 is an E3 ubiquitin ligase ligand, which can be used for the synthesis of PROTAC molecules. For example, Me-SJ46411 combined with PROTAC linker Boc-Piperazine-OH (HY-20797) and target protein ligand (+)-JQ-1 (HY-13030) can be used to synthesize the selective BRD3 PROTAC degrader SJ46420 (HY-168635). .
|
-
- HY-132994
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TVD-0003510 is a carboxamide derivative, and involves in synthesis of (2-((6-(2-aminopyrimidine-5-carboxamido)-8-methoxy-3,4-dihydro-2H-pyrimido[1,2-c]quinazolin-9-yl)oxy)ethyl)piperazine-l-carboxylate (C51), as a part of tert-butyl2-(4-hydroxyphenyl)acetate .
|
-
- HY-161177
-
|
|
PROTACs
Ras
|
Infection
|
|
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .
|
-
- HY-143232
-
|
|
Fungal
Bacterial
|
Infection
Cancer
|
|
Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM .
|
-
- HY-160221
-
|
|
PROTACs
Androgen Receptor
|
Cancer
|
|
PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC50 value of 3 nM. PROTAC AR Degrader-7 is composed of PROTAC target protein ligand AR ligand-32 (HY-170303) (red part), E3 ligase ligand E3 ligase Ligand 44 (HY-170304) (blue part) and PROTAC Linker N-Boc-piperazine (HY-30105) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 145 (HY-170305) .
|
-
- HY-147371
-
|
|
Parasite
|
Infection
Neurological Disease
|
|
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP S c levels - .
|
-
- HY-155075
-
|
|
PROTACs
Glutathione Peroxidase
Ferroptosis
|
Cancer
|
|
NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design . NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832); an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377); the active control for the target protein ligand is RSL3-4-Me (HY-169375).
|
-
- HY-145925C
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
(S,R)-CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S,R)-CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S,R)-CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 (HY-169988), an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1-(3,3-Difluoro-4-piperidinyl)piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990) .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W001978
-
|
|
Biochemical Assay Reagents
|
|
1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W001990
-
|
1-(Pyridin-2-yl)Piperazine
|
Indicators
|
|
1-(2-Pyridyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-40041
-
|
|
Biochemical Assay Reagents
|
|
(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-148830
-
|
|
Drug Delivery
|
|
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-W002603
-
|
|
Biochemical Assay Reagents
|
|
Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-41939
-
|
|
Gene Sequencing and Synthesis
|
|
1-(2-Hydroxyethyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-157920
-
|
N-Biotinyl-N'-[2-(N-maleimido)ethyl]Piperazine
|
Biochemical Assay Reagents
|
|
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
|
-
- HY-W414406
-
|
|
Buffer Reagents
|
|
CABS is a zwitterionic piperazine buffer reagent, which can be used as a buffer reagent for wetting agents, pesticide emulsifiers, and dispersants, and has been used in fluorescent dyeing applications .
|
-
- HY-W008865
-
|
|
Buffer Reagents
|
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
|
-
- HY-157919
-
|
N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]Piperazine, hydrochloride
|
Biochemical Assay Reagents
|
|
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-148830
-
|
|
|
Cationic Lipids
|
|
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
|
-
- HY-160552
-
|
|
|
Cationic Lipids
|
|
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
|
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