2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-C4-NH2 hydrochloride

(S,R,S)-AHPC-C4-NH2 hydrochloride  (Synonyms: VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28)

Cat. No.: HY-114176 Purity: 95.08%
SDS COA Handling Instructions

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(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-C4-NH2 hydrochloride Chemical Structure

CAS No. : 2245697-83-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 605 In-stock
Solution
10 mM * 1 mL in DMSO USD 605 In-stock
Solid
50 mg USD 344 Get quote
100 mg USD 550 Get quote
500 mg USD 1950 Get quote
1 g USD 3350 Get quote
2 g USD 4900 Get quote
5 g   Get quote  
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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-C4-NH2 hydrochloride:

(S,R,S)-AHPC-C4-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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  • Purity & Documentation

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Description

(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-C4-NH2 hydrochloride Related Antibodies
Molecular Weight

566.16

Formula

C27H40ClN5O4S
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 109.6 mg/mL (193.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (88.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7663 mL 8.8314 mL 17.6629 mL
5 mM 0.3533 mL 1.7663 mL 3.5326 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (252 KB)

COA (257 KB) HNMR (138 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.7663 mL 8.8314 mL 17.6629 mL 44.1571 mL
5 mM 0.3533 mL 1.7663 mL 3.5326 mL 8.8314 mL
10 mM 0.1766 mL 0.8831 mL 1.7663 mL 4.4157 mL
15 mM 0.1178 mL 0.5888 mL 1.1775 mL 2.9438 mL
20 mM 0.0883 mL 0.4416 mL 0.8831 mL 2.2079 mL
25 mM 0.0707 mL 0.3533 mL 0.7065 mL 1.7663 mL
30 mM 0.0589 mL 0.2944 mL 0.5888 mL 1.4719 mL
40 mM 0.0442 mL 0.2208 mL 0.4416 mL 1.1039 mL
50 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8831 mL
60 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7360 mL
80 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5520 mL
DMSO 100 mM 0.0177 mL 0.0883 mL 0.1766 mL 0.4416 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-C4-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C4-NH22245697-83-8VH032-C4-NH2 VHL Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 28E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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