SPK-601 (Synonyms: LMV-601)

Cat. No.: HY-70083 Purity: 98.46%: FAQs
Data Sheet SDS COA Handling Instructions

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SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). SPK-601 also can be used as an antimicrobial agent.

For research use only. We do not sell to patients.

SPK-601 Chemical Structure

CAS No. : 1096687-52-3

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 254	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 394	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1183	In-stock	Estimated Time of Arrival: December 31
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200 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

SPK-601 (LMV-601) is an inhibitor of the phosphatidylcholine-specific phospholipase C (PC-PLC). SPK-601 also can be used as an antimicrobial agent^[1].

IC₅₀ & Target

PC-PLC^[1]

In Vitro

SPK-601 (72 hours; HPV-31 cells) displays a dose dependent inhibitory effect on cell growth (IC₅₀ of 16 μg/mL), and inhibits HPV-31 specific RNA expression and DNA replication^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	9E human papilloma virus (HPV)-31 infected cervical epithelial cells
Concentration:
Incubation Time:	72 hours
Result:	A dose dependent inhibitory effect on cell growth.

Molecular Weight

266.46

Formula

C₁₁H₁₅KOS₂

CAS No.

1096687-52-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

[H][C@]12[C@@]3([C@H](C[C@]([H])([C@@]1([H])CCC2)C3)OC(S[K])=S)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 1 mg/mL (3.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7528 mL	18.7642 mL	37.5285 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.46%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (278 KB)

Handling Instructions (2659 KB)

References

[1]. Walker K.Interscience Conference on Antimicrobial Agents and Chemotherapy - 50th Annual Meeting - Research on Promising New Agents: Part 1.IDrugs. 2010 Nov;13(11):743-5. [Content Brief]

[2]. E. Amtmann, et al. Inhibition of high risk HPV-31 in human cervical epithelial cells in vitro by the PC-PLC inhibitor LMV-601. ICID, March 2010, 14: e465.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO

1 mM

3.7528 mL

18.7642 mL

37.5285 mL

93.8211 mL

SPK-601 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPK-6011096687-52-3LMV-601SPK601SPK 601LMV601LMV 601PhospholipaseReverse TranscriptaseInhibitorinhibitorinhibit

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