Sortin1

Cat. No.: HY-12827 Purity: 99.04%: FAQs
Data Sheet SDS COA Handling Instructions

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Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers.

For research use only. We do not sell to patients.

Sortin1 Chemical Structure

CAS No. : 503837-98-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 462	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 462	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Purity & Documentation
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Description

Sortin1 is a chemical genetic-hit molecule that causes specific mislocalization of plant and yeast-soluble and membrane vacuolar markers. IC50 value: Target: Vacuolar markers in vitro: In Arabidopsis seedlings, application of Sortin1 and -2 led to reversible defects in vacuole biogenesis and root development. Sortin1 was found to redirect the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis suspension cells and cause these proteins to be secreted. Sortin1 treatment of whole Arabidopsis seedlings also resulted in carboxypeptidase Y secretion, indicating that the drug has a similar mode of action in cells and intact plants [1]. Structure-activity relationship studies conducted in Arabidopsis revealed the structural requirements for Sortin1 bioactivity and demonstrated that overlapping Sortin1 substructures can be used to discriminate between vacuolar-flavonoid accumulations and vacuolar-biogenesis defects [2].

Molecular Weight

441.43

Formula

C₂₆H₁₉NO₆

CAS No.

503837-98-7

Appearance

Solid

Color

Orange to red

SMILES

O=C(C1=C(C)NC2=C(C(C3=C2C=CC=C3)=O)C1C4=CC=C(C5=CC=C(C(O)=O)C=C5)O4)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2654 mL	11.3268 mL	22.6536 mL
5 mM	0.4531 mL	2.2654 mL	4.5307 mL
10 mM	0.2265 mL	1.1327 mL	2.2654 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.04%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (258 KB) HNMR (262 KB) RP-HPLC (870 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Zouhar J, et al. Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9497-501. [Content Brief]

[2]. Rosado A, et al. Sortin1-hypersensitive mutants link vacuolar-trafficking defects and flavonoid metabolism in Arabidopsis vegetative tissues. Chem Biol. 2011 Feb 25;18(2):187-97. [Content Brief]

[3]. Orr DJ, et al. 1H NMR-based metabolomics methods for chemical genomics experiments. Methods Mol Biol. 2014;1056:225-39. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2654 mL	11.3268 mL	22.6536 mL	56.6341 mL
	5 mM	0.4531 mL	2.2654 mL	4.5307 mL	11.3268 mL
	10 mM	0.2265 mL	1.1327 mL	2.2654 mL	5.6634 mL
	15 mM	0.1510 mL	0.7551 mL	1.5102 mL	3.7756 mL
	20 mM	0.1133 mL	0.5663 mL	1.1327 mL	2.8317 mL
	25 mM	0.0906 mL	0.4531 mL	0.9061 mL	2.2654 mL
	30 mM	0.0755 mL	0.3776 mL	0.7551 mL	1.8878 mL
	40 mM	0.0566 mL	0.2832 mL	0.5663 mL	1.4159 mL
	50 mM	0.0453 mL	0.2265 mL	0.4531 mL	1.1327 mL
	60 mM	0.0378 mL	0.1888 mL	0.3776 mL	0.9439 mL
	80 mM	0.0283 mL	0.1416 mL	0.2832 mL	0.7079 mL
	100 mM	0.0227 mL	0.1133 mL	0.2265 mL	0.5663 mL

Sortin1 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sortin1503837-98-7Sortin 1Sortin-1OthersInhibitorinhibitorinhibit

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