Sultopride (Synonyms: LIN-1418)

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Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sultopride hydrochloride) usually boasts enhanced water solubility and stability.

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Sultopride Chemical Structure

CAS No. : 53583-79-2

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Other In-stock Forms of Sultopride:

Sultopride hydrochloride

Other Forms of Sultopride:

Sultopride hydrochloride In-stock
Sultopride-d5 Get quote

1 Publications Citing Use of MCE Sultopride

•Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Abstract]

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description	Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.
IC₅₀ & Target	Dopamine D2 receptor^[1]
In Vivo	Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	354.46
Formula	C₁₇H₂₆N₂O₄S
CAS No.	53583-79-2
SMILES	O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(CC)=O)=CC=C2OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Moriuchi K, et al. Differences in effects of sultopride and sulpiride on dopamine turnover in rat brain. Neurochem Res. 1995 Jan;20(1):95-9. [Content Brief]

Animal Administration
^[1]

Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Moriuchi K, et al. Differences in effects of sultopride and sulpiride on dopamine turnover in rat brain. Neurochem Res. 1995 Jan;20(1):95-9. [Content Brief]

Sultopride Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sultopride53583-79-2LIN-1418LIN1418LIN 1418Dopamine ReceptordopamineD2receptorDOPACHVAlevelsstriatumInhibitorinhibitorinhibit

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