2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Sultopride hydrochloride

Sultopride hydrochloride  (Synonyms: LIN-1418 hydrochloride)

Cat. No.: HY-42849A Purity: 99.92%
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Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.

For research use only. We do not sell to patients.

Sultopride hydrochloride Chemical Structure

Sultopride hydrochloride Chemical Structure

CAS No. : 23694-17-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 121 In-stock
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10 mM * 1 mL in Water USD 121 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 175 In-stock
25 mg USD 350 In-stock
50 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sultopride hydrochloride:

Sultopride hydrochloride Related Antibodies

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1 Publications Citing Use of MCE Sultopride hydrochloride

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  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.

IC50 & Target

Dopamine D2 receptor[1]
In Vivo

Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride hydrochloride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

390.93

Formula

C17H27ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(CC)=O)=CC=C2OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (127.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5580 mL 12.7900 mL 25.5800 mL
5 mM 0.5116 mL 2.5580 mL 5.1160 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 140 mg/mL (358.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
Animal Administration
[1]

Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride hydrochloride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5580 mL 12.7900 mL 25.5800 mL 63.9501 mL
5 mM 0.5116 mL 2.5580 mL 5.1160 mL 12.7900 mL
10 mM 0.2558 mL 1.2790 mL 2.5580 mL 6.3950 mL
15 mM 0.1705 mL 0.8527 mL 1.7053 mL 4.2633 mL
20 mM 0.1279 mL 0.6395 mL 1.2790 mL 3.1975 mL
25 mM 0.1023 mL 0.5116 mL 1.0232 mL 2.5580 mL
30 mM 0.0853 mL 0.4263 mL 0.8527 mL 2.1317 mL
40 mM 0.0640 mL 0.3198 mL 0.6395 mL 1.5988 mL
50 mM 0.0512 mL 0.2558 mL 0.5116 mL 1.2790 mL
60 mM 0.0426 mL 0.2132 mL 0.4263 mL 1.0658 mL
80 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7994 mL
100 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6395 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sultopride hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sultopride23694-17-9LIN-1418LIN1418LIN 1418Dopamine ReceptordopamineD2receptorDOPACHVAlevelsstriatumInhibitorinhibitorinhibit

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