2. PI3K/Akt/mTOR
  3. PI3K
  4. Umbralisib R-enantiomer

Umbralisib R-enantiomer  (Synonyms: TGR-1202 R-enantiomer; RP5264 R-enantiomer)

Cat. No.: HY-12279F Purity: 99.52%
SDS COA Handling Instructions

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Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.

For research use only. We do not sell to patients.

Umbralisib R-enantiomer Chemical Structure

Umbralisib R-enantiomer Chemical Structure

CAS No. : 1532533-69-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 729 In-stock
Solution
10 mM * 1 mL in DMSO USD 729 In-stock
Solid
1 mg USD 240 In-stock
5 mg USD 580 In-stock
10 mg USD 850 In-stock
25 mg USD 1500 In-stock
50 mg USD 1950 In-stock
100 mg USD 2530 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Umbralisib R-enantiomer:

Umbralisib R-enantiomer Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.

IC50 & Target[1]

PI3Kδ

 

In Vitro

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Umbralisib R-enantiomer Related Antibodies
Molecular Weight

571.55

Formula

C31H24F3N5O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(C2=CC=CC(F)=C2)=C([C@@H](C)N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)OC6=CC=C(F)C=C16
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (58.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7496 mL 8.7481 mL 17.4963 mL
5 mM 0.3499 mL 1.7496 mL 3.4993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52%

SDS (252 KB)

COA (255 KB) LCMS (135 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7496 mL 8.7481 mL 17.4963 mL 43.7407 mL
5 mM 0.3499 mL 1.7496 mL 3.4993 mL 8.7481 mL
10 mM 0.1750 mL 0.8748 mL 1.7496 mL 4.3741 mL
15 mM 0.1166 mL 0.5832 mL 1.1664 mL 2.9160 mL
20 mM 0.0875 mL 0.4374 mL 0.8748 mL 2.1870 mL
25 mM 0.0700 mL 0.3499 mL 0.6999 mL 1.7496 mL
30 mM 0.0583 mL 0.2916 mL 0.5832 mL 1.4580 mL
40 mM 0.0437 mL 0.2187 mL 0.4374 mL 1.0935 mL
50 mM 0.0350 mL 0.1750 mL 0.3499 mL 0.8748 mL
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Umbralisib R-enantiomer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Umbralisib R-enantiomer1532533-69-9TGR-1202 R-enantiomer RP5264 R-enantiomerPI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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