2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 1

TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.

For research use only. We do not sell to patients.

TLR7 agonist 1 Chemical Structure

TLR7 agonist 1 Chemical Structure

CAS No. : 2178156-33-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

TLR7 agonist 1 Related Antibodies

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Description

TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.

IC50 & Target[1]

TLR7

90 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
> 25 μM
Compound: 48
Cytotoxic activity against HEK293 cells assessed as reduction in cell viability incubated for 6 hrs
Cytotoxic activity against HEK293 cells assessed as reduction in cell viability incubated for 6 hrs
[PMID: 29366653]
Molecular Weight

363.46

Formula

C21H25N5O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC2=C(C(C(N[C@@H](C)C3=CC=CC=C3)=O)=CC=C2)C(NCCCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (275.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7513 mL 13.7567 mL 27.5133 mL
5 mM 0.5503 mL 2.7513 mL 5.5027 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7513 mL 13.7567 mL 27.5133 mL 68.7834 mL
5 mM 0.5503 mL 2.7513 mL 5.5027 mL 13.7567 mL
10 mM 0.2751 mL 1.3757 mL 2.7513 mL 6.8783 mL
15 mM 0.1834 mL 0.9171 mL 1.8342 mL 4.5856 mL
20 mM 0.1376 mL 0.6878 mL 1.3757 mL 3.4392 mL
25 mM 0.1101 mL 0.5503 mL 1.1005 mL 2.7513 mL
30 mM 0.0917 mL 0.4586 mL 0.9171 mL 2.2928 mL
40 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7196 mL
50 mM 0.0550 mL 0.2751 mL 0.5503 mL 1.3757 mL
60 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1464 mL
80 mM 0.0344 mL 0.1720 mL 0.3439 mL 0.8598 mL
100 mM 0.0275 mL 0.1376 mL 0.2751 mL 0.6878 mL
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TLR7 agonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 12178156-33-5Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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