2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. TRAP-6

TRAP-6  (Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6)

Cat. No.: HY-P0078 Purity: 99.84%
SDS COA Handling Instructions

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TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TRAP-6 Chemical Structure

TRAP-6 Chemical Structure

CAS No. : 141136-83-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in Water USD 165 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 352 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

TRAP-6 Related Antibodies

Top Publications Citing Use of Products

    TRAP-6 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Jun;19(6):5291-5300.  [Abstract]

    Detection of expression levels of p‑AKT, AKT, p‑JNK, JNK and NF‑κB using western blotting. Groups: NC, negative control group; CH, a cholesterol stimulation group; CH+T, cholesterol stimulation with TRAP‑6 treatment group; CH+V, cholesterol stimulation with vorapaxar treatment group.

    View All Protease Activated Receptor (PAR) Isoform Specific Products:

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    PAR1 PAR2 PAR4

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

    IC50 & Target

    PAR1

    96 nM (IC50)

    PAR1

     

    In Vitro

    TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
    TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
    TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    TRAP-6 Related Antibodies
    In Vivo

    TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    748.87

    Formula

    C34H56N10O9
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ser-Phe-Leu-Leu-Arg-Asn
    Sequence Shortening

    SFLLRN
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (33.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3353 mL 6.6767 mL 13.3535 mL
    5 mM 0.2671 mL 1.3353 mL 2.6707 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.84%

    SDS (393 KB)

    COA (255 KB) LCMS (260 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3353 mL 6.6767 mL 13.3535 mL 33.3836 mL
    5 mM 0.2671 mL 1.3353 mL 2.6707 mL 6.6767 mL
    10 mM 0.1335 mL 0.6677 mL 1.3353 mL 3.3384 mL
    15 mM 0.0890 mL 0.4451 mL 0.8902 mL 2.2256 mL
    20 mM 0.0668 mL 0.3338 mL 0.6677 mL 1.6692 mL
    25 mM 0.0534 mL 0.2671 mL 0.5341 mL 1.3353 mL
    30 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    TRAP-6 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TRAP-6141136-83-6PAR-1 agonist peptide Thrombin Receptor Activator Peptide 6TRAP6TRAP 6Thrombin Receptor Activator Peptide6Thrombin Receptor Activator Peptide 6Thrombin Receptor Activator Peptide-6Protease Activated Receptor (PAR)Thrombin receptorsproteaseactivatingreceptorPAR1plateletsthrombinInhibitorinhibitorinhibit

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