1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. β-glucuronidase

β-glucuronidase

GUSB

β-glucuronidase is a glycoside hydrolase widely distributed in mammalian tissues, body fluids, microbiota, plants, fish, insects and mollusks. β-glucuronidase belongs to GH family 1, 2, 30, 79, 154 and GH-A. β-glucuronidase can hydrolyze estrogen glucuronides, regulate the enterohepatic circulation and reabsorption of estrogen, and affect estrogen metabolism. β-glucuronidase can also hydrolyze the extracellular sugar residues on the TRPV5 channel, trapping it in the plasma membrane, maintaining calcium channel activity and membrane calcium permeability. This target is related to many disease areas. For example, in cancer, its increased activity is related to the occurrence and development of colorectal cancer, breast cancer, ovarian cancer, etc.; in metabolic diseases, it is related to diabetes and its induced periodontitis; in inflammatory diseases, it involves bacterial peritonitis, bacterial meningitis, pelvic inflammatory disease, etc.; in addition, it is also related to diseases such as endometriosis[1][2][3][4][5][6][7].

β-glucuronidase Related Products (35):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137816
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium
    Substrate
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage.
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium
  • HY-N7529
    Siastatin B
    Inhibitor
    Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase.
    Siastatin B
  • HY-N3413
    Kushenol X
    Inhibitor
    Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively.
    Kushenol X
  • HY-151166
    β-Glucuronidase-IN-2
    Inhibitor
    β-Glucuronidase-IN-2 is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.24 μM, an Ki value of 1.09 μM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies.
    β-Glucuronidase-IN-2
  • HY-150973
    hCAII-IN-4
    Inhibitor
    hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC50 of 7.78 μM. hCAII-IN-4 also inhibits β-glucuronidase with an IC50 of 773.9 μM.
    hCAII-IN-4
  • HY-137426A
    Phenolphthalein glucuronide sodium
    Substrate
    Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase.
    Phenolphthalein glucuronide sodium
  • HY-N1322
    Sanggenol A
    Inhibitor
    Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase.
    Sanggenol A
  • HY-P2803B
    Beta-glucuronidase (helix pomatia)
    Chemical
    Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate.
    Beta-glucuronidase (helix pomatia)
  • HY-D1578
    C12FDGlcU
    C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of β-glucuronidase (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm).
    C12FDGlcU
  • HY-W283888
    5-Bromo-4-chloro-1H-indol-3-yl nonanoate
    Substrate
    5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.
    5-Bromo-4-chloro-1H-indol-3-yl nonanoate
  • HY-D0164
    Naphthol AS-BI
    Substrate
    Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.
    Naphthol AS-BI
  • HY-N9975
    4'',5''-Dehydroisopsoralidin
    Inhibitor
    4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.
    4'',5''-Dehydroisopsoralidin
  • HY-N1735
    2′-Hydroxygenistein
    Inhibitor
    2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively.
    2′-Hydroxygenistein
  • HY-D0935
    4-Methylumbelliferyl-β-D-glucuronide
    Substrate
    4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λex=362 nm, λem=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli.
    4-Methylumbelliferyl-β-D-glucuronide
  • HY-162884
    β-Glucuronidase-IN-4
    Inhibitor
    EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC50 of 2.68 μM and a Ki value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity.
    β-Glucuronidase-IN-4