1. Signaling Pathways
  2. Neuronal Signaling
    Stem Cell/Wnt
  3. γ-secretase
  4. γ-secretase Modulator

γ-secretase Modulator

γ-secretase Modulators (26):

Cat. No. Product Name Effect Purity
  • HY-115726A
    (-)-FRM-024
    Modulator
    (-)-FRM-024 is the (-)-isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research.
  • HY-10016
    E 2012
    Modulator
    E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.
  • HY-120789
    PF-06648671
    Modulator 98.12%
    PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease.
  • HY-108714
    NGP555
    Modulator 98.77%
    NGP555 is a γ-secretase modulator. NGP555 Lowers the Amyloid Biomarker Aβ42.
  • HY-117482
    BPN-15606
    Modulator 99.96%
    BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance.
  • HY-145343
    RO7185876
    Modulator 99.04%
    RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.
  • HY-B1786A
    (E/Z)-Sulindac sulfide
    Modulator 99.88%
    (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease.
  • HY-100604
    JNJ-40418677
    Modulator ≥99.0%
    JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research.
  • HY-115726
    FRM-024
    Modulator 99.45%
    FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.
  • HY-119165
    GSM-1
    Modulator 98.39%
    GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1).
  • HY-10043
    gamma-secretase modulator 1
    Modulator ≥98.0%
    γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
  • HY-50754
    gamma-secretase modulator 2
    Modulator 98.80%
    gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease IC50 value: Target: γ-secretase γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain.
  • HY-10043A
    gamma-secretase modulator 1 hydrochloride
    Modulator 99.85%
    gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.
  • HY-128581
    γ-Secretase modulator 4
    Modulator 99.47%
    γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively.
  • HY-50889
    gamma-secretase modulator 3
    Modulator ≥98.0%
    gamma-secretase modulator 3 is a gamma-secretase modulator.
  • HY-130609A
    Aβ42-IN-1 free base
    Modulator
    Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
  • HY-112282
    BI-1408
    Modulator
    BI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for 42.
  • HY-103537
    (Rac)-BIIB042
    Modulator
    (Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease.
  • HY-145372
    γ-Secretase modulator 10
    Modulator
    γ-Secretase modulator 10 is a novel γ-secretase modulator.
  • HY-117482A
    BPN-15606 besylate
    Modulator
    BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.