γ-secretase Modulator

γ-secretase Modulators (26):

Cat. No.	Product Name	Effect	Purity

HY-115726A

(-)-FRM-024	Modulator
(-)-FRM-024 is the (-)-isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research.

HY-10016

E 2012	Modulator
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.

HY-120789

PF-06648671	Modulator	98.12%
PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease.

HY-117482

BPN-15606	Modulator	99.96%
BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC₅₀ values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance.

HY-108714

NGP555	Modulator	98.04%
NGP555 is a γ-secretase modulator. NGP555 Lowers the Amyloid Biomarker Aβ42.

HY-B1786A

(E/Z)-Sulindac sulfide	Modulator	99.88%
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease.

HY-145343

RO7185876	Modulator	99.04%
RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.

HY-119165

GSM-1	Modulator	98.39%
GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1).

HY-100604

JNJ-40418677	Modulator	≥99.0%
JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC₅₀s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimer’s disease research.

HY-115726

FRM-024	Modulator	99.45%
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.

HY-10043

gamma-secretase modulator 1	Modulator	≥98.0%
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

HY-50754

gamma-secretase modulator 2	Modulator	98.80%
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease IC50 value: Target: γ-secretase γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain.

HY-10043A

gamma-secretase modulator 1 hydrochloride	Modulator	99.85%
gamma-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

HY-128581

γ-Secretase modulator 4	Modulator	99.47%
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC₅₀s of 0.014 μM and 0.017 μM in human and mouse, respectively.

HY-50889

gamma-secretase modulator 3	Modulator	≥98.0%
gamma-secretase modulator 3 is a gamma-secretase modulator.

HY-130609A

Aβ42-IN-1 free base	Modulator
Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC₅₀ value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.

HY-112282

BI-1408	Modulator
BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂.

HY-103537

(Rac)-BIIB042	Modulator
(Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC₅₀ value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease.

HY-145372

γ-Secretase modulator 10	Modulator
γ-Secretase modulator 10 is a novel γ-secretase modulator.

HY-117482A

BPN-15606 besylate	Modulator
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC₅₀ values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance.

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