2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. DM3

DM3  (Synonyms: Maytansinoid DM3)

Cat. No.: HY-130080 Purity: 95.59%
COA Handling Instructions

Molarity Calculator

DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DM3 Chemical Structure

DM3 Chemical Structure

CAS No. : 796073-54-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 781 In-stock
Solution
10 mM * 1 mL in DMSO USD 781 In-stock
Solid
1 mg USD 284 In-stock
5 mg USD 710 In-stock
10 mg USD 1200 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

DM3 Related Antibodies

Top Publications Citing Use of Products

View All ADC Cytotoxin Isoform Specific Products:

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  • Customer Review

Description

DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Maytansinoids

 

Molecular Weight

766.34

Formula

C37H52ClN3O10S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (130.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3049 mL 6.5245 mL 13.0490 mL
5 mM 0.2610 mL 1.3049 mL 2.6098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.59%

COA (261 KB) HNMR (530 KB) RP-HPLC (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3049 mL 6.5245 mL 13.0490 mL 32.6226 mL
5 mM 0.2610 mL 1.3049 mL 2.6098 mL 6.5245 mL
10 mM 0.1305 mL 0.6525 mL 1.3049 mL 3.2623 mL
15 mM 0.0870 mL 0.4350 mL 0.8699 mL 2.1748 mL
20 mM 0.0652 mL 0.3262 mL 0.6525 mL 1.6311 mL
25 mM 0.0522 mL 0.2610 mL 0.5220 mL 1.3049 mL
30 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0874 mL
40 mM 0.0326 mL 0.1631 mL 0.3262 mL 0.8156 mL
50 mM 0.0261 mL 0.1305 mL 0.2610 mL 0.6525 mL
60 mM 0.0217 mL 0.1087 mL 0.2175 mL 0.5437 mL
80 mM 0.0163 mL 0.0816 mL 0.1631 mL 0.4078 mL
100 mM 0.0130 mL 0.0652 mL 0.1305 mL 0.3262 mL
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DM3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DM3796073-54-6Maytansinoid DM3DM 3DM-3Maytansinoid DM 3Maytansinoid DM-3ADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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