2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. Maytansinoid DM4

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC.

For research use only. We do not sell to patients.

Maytansinoid DM4 Chemical Structure

Maytansinoid DM4 Chemical Structure

CAS No. : 799840-96-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Maytansinoid DM4:

Maytansinoid DM4 Related Antibodies

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Description

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

IC50 & Target[1][2]

Maytansinoids

 

In Vitro

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Maytansinoid DM4 Related Antibodies
Molecular Weight

794.39

Formula

C39H56ClN3O10S
CAS No.
SMILES

C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)[C@@](C(C)([C@](OC4=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N4)O)C)([H])O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Maytansinoid DM4 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maytansinoid DM4799840-96-3Maytansinoid DM 4Maytansinoid DM-4ADC CytotoxinADC PayloadADCthiolmaytansinecytotoxintubulinanti-cancerInhibitorinhibitorinhibit

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