Aminopeptidase

Aminopeptidase Related Products (55):

By Effects:	Substrates (2) Inhibitors (47) Antagonist (1) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-113952

Actinonin	Inhibitor	98.61%
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.

HY-133125

ERAP1-IN-1	Inhibitor	98.79%
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates.

HY-101932

TNP-470	Inhibitor	99.87%
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-103226

SC-57461A	Inhibitor	99.89%
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively.

HY-14807

Tosedostat	Inhibitor	99.75%
Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines.

HY-19876

PL37	Antagonist
PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating μ-opioid receptors (µ-opioid receptors), with an ED₅₀ value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain.

HY-10826

DG051 free acid	Inhibitor
DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke.

HY-118661

BDM14471	Inhibitor
BDM14471 is a selective inhibitor of hydroxamate aminopeptidase M1 (PfAM1), with the IC₅₀ of 6 nM.

HY-109058

Firibastat	Inhibitor	≥98.0%
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (K_i=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.

HY-150504

ERAP2-IN-1	Inhibitor	98.86%
ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC₅₀ of 27 μM and model peptide hydrolysis with an IC₅₀ of 44 μM.

HY-110259

HFI-142	Inhibitor	99.55%
HFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a K_i of 2.01 μM.

HY-W015876

L-Leucinol	Inhibitor	99.53%
L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with K_i value of 17 μM.

HY-160239

HFI-437	Inhibitor	99.64%
HFI-437 is a potent non-peptidic insulin-regulated aminopeptidase (IRAP) inhibitor with a K_i of 20 nM. HFI-437 is a cognitive enhancer.

HY-151518

Aminopeptidase-IN-1	Inhibitor	98.02%
Aminopeptidase-IN-1 (compound 16o) is a potent insulin-regulated aminopeptidase (IRAP) inhibitor with an K_i value of 7.7 μM. Aminopeptidase-IN-1 can be used tor research cognitive and memory impairments.

HY-W027340

ARM1	Inhibitor	99.60%
ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM.

HY-10825

DG051	Inhibitor	99.86%
DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC₅₀=47 nM.

HY-W004291

Methyl arachidate	Inhibitor	≥98.0%
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor.

HY-121123

Adamantanine	Inhibitor
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5.

HY-17625

Acebilustat	Inhibitor	99.67%
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.

HY-P4549

H-D-Ala-D-Ala-D-Ala-D-Ala-OH
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase.

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